Double-Target attack: new CAR T-Cell therapy takes on tough lymphoma

NCT ID NCT05826535

Recruiting now Disease control Sponsor: Lyell Immunopharma, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 26 times

Summary

This study tests a new treatment called ronde-cel for people with aggressive B-cell lymphoma that has come back or not responded to at least two prior therapies. The treatment uses a patient's own immune cells that are modified to target two markers (CD19 and CD20) on cancer cells. The goal is to see if this dual-targeting approach is safe and effective in shrinking tumors.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Atrium Health Wake Forest Baptist
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Augusta University Medical Center
RECRUITING

Augusta, Georgia, 30912, United States
Baylor University Medical Center
RECRUITING

Dallas, Texas, 75246, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Corewell Health
RECRUITING

Grand Rapids, Michigan, 49503, United States
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10021, United States
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Indiana Blood and Marrow Transplantation
RECRUITING

Indianapolis, Indiana, 46237, United States
Intermountain Healthcare
RECRUITING

Salt Lake City, Utah, 84143, United States
Lehigh Valley Topper Cancer Center Institute
RECRUITING

Allentown, Pennsylvania, 18103, United States
Louisiana State University Health Sciences Center
RECRUITING

Shreveport, Louisiana, 71130, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14263, United States
Scripps Clinic
RECRUITING

San Diego, California, 92037, United States
Texas Transplant Institute
RECRUITING

San Antonio, Texas, 78229, United States
The Alfred Hospital
RECRUITING

Melbourne, 3004, Australia
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University of California, Los Angeles (UCLA) Medical Center
RECRUITING

Los Angeles, California, 90095, United States
University of California-Irvine Medical Center
RECRUITING

Irvine, California, 92697, United States
University of Cincinnati (UC) Physicians Company, LLC
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Louisville Brown Cancer Center
RECRUITING

Louisville, Kentucky, 40202, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of New Mexico Comprehensive Cancer Center
RECRUITING

Albuquerque, New Mexico, 87131, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37212, United States
Virginia Commonwealth University-Massey Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 24502, United States
West Penn Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States

Conditions

Explore the condition pages connected to this study.

LARGE B-CELL LYMPHOMA LARGE B-CELL LYMPHOMA NON-HODGKIN LYMPHOMA REFRACTORY NON-HODGKIN LYMPHOMA RELAPSED NON HODGKIN LYMPHOMA