New drug interaction study for myelofibrosis treatment completed
NCT ID NCT06024915
First seen Jan 06, 2026 · Last updated Jun 22, 2026 · Updated 25 times
Summary
This phase 1 trial tested how TQ05105 tablets, a drug for myelofibrosis, interact with other drugs that affect liver enzymes. 40 healthy adults took TQ05105 alone and with itraconazole or rifampicin. Researchers measured drug levels and safety to understand how these combinations change the drug's effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Shandong Provincial Hospital
Jinan, Shandong, 250021, China
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TQ05105 tablets (a JAK2 inhibitor)
What this could lead to
If successful, this study will show how TQ05105 interacts with other drugs, helping doctors use it safely for myelofibrosis.
What could go wrong
This is a very early, small study in healthy people, not patients. It only tests drug interactions, not whether TQ05105 works for myelofibrosis.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.