Could a single drug replace the standard triple therapy for rectal cancer?

NCT ID NCT05723562

Ongoing Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Nov 15, 2025 · Last updated May 21, 2026 · Updated 26 times

Summary

This study tests whether the immunotherapy drug dostarlimab alone can effectively treat people with a specific type of advanced rectal cancer (dMMR/MSI-H) that has not been treated before. About 154 participants will receive dostarlimab and be closely monitored. The goal is to see if the drug can make the cancer disappear completely and stay gone for at least 12 months, allowing patients to avoid chemotherapy, radiation, and surgery.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

GSK Investigational Site

Los Angeles, California, 90027, United States
GSK Investigational Site

Albuquerque, New Mexico, 87131, United States
GSK Investigational Site

New York, New York, 10022, United States
GSK Investigational Site

Pittsburgh, Pennsylvania, 15232, United States
GSK Investigational Site

Nashville, Tennessee, 37203, United States
GSK Investigational Site

Dallas, Texas, 75390, United States
GSK Investigational Site

Richmond, Virginia, 23298, United States
GSK Investigational Site

Ottawa, Ontario, K1H 8L6, Canada
GSK Investigational Site

Toronto, Ontario, M5G 2M9, Canada
GSK Investigational Site

Montreal, Quebec, H2X 0C1, Canada
GSK Investigational Site

Sherbrooke, Quebec, J1H 5N4, Canada
GSK Investigational Site

Besançon, 25030, France
GSK Investigational Site

Marseille, 13273, France
GSK Investigational Site

Paris, 75012, France
GSK Investigational Site

Pessac, 33604, France
GSK Investigational Site

Rennes, 35000, France
GSK Investigational Site

Berlin, 13353, Germany
GSK Investigational Site

Dresden, 01307, Germany
GSK Investigational Site

Düsseldorf, 40225, Germany
GSK Investigational Site

Frankfurt, 60488, Germany
GSK Investigational Site

München, 81377, Germany
GSK Investigational Site

Milan, 20133, Italy
GSK Investigational Site

Padova, 35128, Italy
GSK Investigational Site

Roma, 00168, Italy
GSK Investigational Site

Chiba, 277-8577, Japan
GSK Investigational Site

Kanagawa, 232-0024, Japan
GSK Investigational Site

Osaka, 540-0006, Japan
GSK Investigational Site

Osaka, 565-0871, Japan
GSK Investigational Site

Utrecht, 3584 CX, Netherlands
GSK Investigational Site

Seoul, 05505, South Korea
GSK Investigational Site

Seoul, 06591, South Korea
GSK Investigational Site

Seoul, 120-752, South Korea
GSK Investigational Site

Seoul, 135-710, South Korea
GSK Investigational Site

Barcelona, 08035, Spain
GSK Investigational Site

Granada, 18014, Spain
GSK Investigational Site

Madrid, 28007, Spain
GSK Investigational Site

Madrid, 28041, Spain
GSK Investigational Site

Santander, 39008, Spain
GSK Investigational Site

Valencia, 46010, Spain
GSK Investigational Site

Leeds West Yorkshire, LS9 7TF, United Kingdom
GSK Investigational Site

London, EC1A 7BE, United Kingdom
GSK Investigational Site

Sutton, SM2 5PT, United Kingdom

Conditions

Explore the condition pages connected to this study.

NEOPLASMS, RECTAL NEOPLASMS, RECTAL