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Could this antibody slow Alzheimer's? new trial results are in

NCT ID NCT03367403

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called donanemab (LY3002813) in 272 people with early symptoms of Alzheimer's disease. The goal was to see if the drug is safe and can slow down memory loss and daily functioning problems. Participants received either the drug or a placebo, and researchers measured changes in thinking skills and daily activities over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

272 people

The number who actually took part.

Started

Dec 2017

Finished

Sep 2021

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Gradual and progressive change in memory function reported by participants or informants for ≥ 6 months. * MMSE score of 20 to 28 (inclusive) at baseline or an acceptable historical flortaucipir PET scan within 6 months prior to baseline that meets the central read criteria. * Meet 18F flortaucipir PET scan eligibility criteria. * Meet 18F florbetapir PET scan (central read) eligibility criteria. Exclusion Criteria: * Have a history of long QT syndrome. * Have received treatment with a stable dose of an acetylcholinesterase inhibitor (AChEI) and/or memantine for less than 2 months before randomization. * Contraindication to MRI.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease

Contacts and locations

Locations

  • Abington Neurological Associates

    Willow Grove, Pennsylvania, 19090, United States

  • ActivMed Practices & Research, Inc

    Methuen, Massachusetts, 01844, United States

  • Advanced Memory Research Institute of New Jersey

    Toms River, New Jersey, 08755, United States

  • Alexian Brothers Medical Center

    Elk Grove Village, Illinois, 60007, United States

  • Associated Neurologists, PC - Danbury

    Danbury, Connecticut, 06810, United States

  • Axiom Research

    Tampa, Florida, 33609, United States

  • Banner Alzheimer's Institute

    Phoenix, Arizona, 85006, United States

  • Banner Sun Health Research Institute

    Sun City, Arizona, 85351, United States

  • Behavioral Health Center Research

    Charlotte, North Carolina, 28211, United States

  • Boston Center for Memory

    Newton, Massachusetts, 02459, United States

  • Bradenton Research Center

    Bradenton, Florida, 34205, United States

  • Brain Matters Research

    Delray Beach, Florida, 33445, United States

  • Bruyere Research Institute

    Ottawa, Ontario, K1N 5C8, Canada

  • Butler Hospital

    Providence, Rhode Island, 02906, United States

  • Clinique de la Memoire de l'Outaouais

    Gatineau, Quebec, J8T 8J1, Canada

  • Cognition Health

    Fairfax, Virginia, 22031, United States

  • Compass Research

    Orlando, Florida, 32806, United States

  • Compass Research

    The Villages, Florida, 32162, United States

  • Cotton O'Neil Clinic

    Topeka, Kansas, 66606, United States

  • DIEX Recherche Sherbrooke, Inc

    Sherbrooke, Quebec, J1L 0H8, Canada

  • Donald S Marks

    Plymouth, Massachusetts, 02360-4843, United States

  • Great Lakes Clinical Trials

    Chicago, Illinois, 60640, United States

  • Guilford Neurologic Associates

    Greensboro, North Carolina, 27405, United States

  • Houston Methodist

    Houston, Texas, 77030, United States

  • Indiana University School of Medicine

    Indianapolis, Indiana, 46202, United States

  • Infinity Clinical Research, LLC

    Hollywood, Florida, 33021, United States

  • Insight Clinical Trials

    Beachwood, Ohio, 44122, United States

  • Institute for Memory Impairment & Neurological Disorders

    Irvine, California, 92697, United States

  • Intercoastal Medical Group

    Sarasota, Florida, 34239, United States

  • Irvine Clinical Research Center

    Irvine, California, 92614, United States

  • JEM Research Institute

    Atlantis, Florida, 33462, United States

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216, United States

  • Josephson Wallack Munshower Neurology

    Indianapolis, Indiana, 46256, United States

  • KI Health Partners, LLC d/b/a NE Inst. for Clin. Res.

    Stamford, Connecticut, 06905, United States

  • Kawartha Regional Memory Clinic

    Peterborough, Ontario, K9H2P4, Canada

  • Las Vegas Medical Research

    Las Vegas, Nevada, 89113, United States

  • McLean Hospital

    Belmont, Massachusetts, 02478, United States

  • Merritt Island Medical Research LLC

    Merritt Island, Florida, 32592, United States

  • Miami Jewish Health Systems

    Miami, Florida, 33137, United States

  • National Clinical Research - Richmond

    Richmond, Virginia, 23294, United States

  • Neurology Center of North Orange County

    Fullerton, California, 92835, United States

  • Neurology Diagnostics, Inc.

    Dayton, Ohio, 45459, United States

  • Ohio State University Medical Center

    Columbus, Ohio, 43210, United States

  • Pacific Research Network Inc

    San Diego, California, 92103, United States

  • Palm Beach Neurological Group

    Palm Beach Gardens, Florida, 33410, United States

  • Pharmacology Research Institute

    Newport Beach, California, 92660, United States

  • Pharmax Research Clinic

    Miami, Florida, 33126, United States

  • Piedmont Medical Research

    Winston-Salem, North Carolina, 27103, United States

  • Progressive Medical Research

    Port Orange, Florida, 32127, United States

  • Quantum Laboratories

    Pompano Beach, Florida, 33064, United States

  • Raleigh Neurology Associates

    Raleigh, North Carolina, 27607, United States

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Sharp Mesa Vista Hospital

    San Diego, California, 92123, United States

  • Stedman Clinical Trials

    Tampa, Florida, 33613, United States

  • Suncoast Clinical Research

    New Port Richey, Florida, 34652, United States

  • Syrentis Clinical Research

    Santa Ana, California, 92705, United States

  • Texas Neurology, PA

    Dallas, Texas, 75214, United States

  • The Memory Clinic

    Bennington, Vermont, 05201, United States

  • Toronto Memory Program

    Toronto, Ontario, M3B2S7, Canada

  • University of Kansas Hospital

    Fairway, Kansas, 66160, United States

  • Washington University

    St Louis, Missouri, 63108, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.