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Can a common solvent make dental fillings last longer?

NCT ID NCT07830641

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers are testing whether pretreating dentin with dimethyl sulfoxide (DMSO) before placing a composite filling improves how well the filling holds up in non-carious cervical lesions, which are worn-away areas near the gum line. Thirty participants with at least two such teeth receive a DMSO pretreatment on one tooth and no pretreatment on another, then both receive standard etch-and-rinse adhesive and composite. Over two years, dentists score the fillings for appearance, function, and signs of decay using FDI criteria. The trial compares whether DMSO makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dimethyl sulfoxide applied to dentin before a composite filling
What this could lead to
If it works, dentists could use a simple pretreatment to make composite fillings last longer and look better in worn-away areas of teeth.
What could go wrong
The trial is small and short, so any benefit may be modest or not hold up in larger groups. DMSO can irritate tissue, and the technique may not work for all teeth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Dec 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:following eligibility criteria: 1. Presence of at least two permanent teeth with non-carious cervical lesions (NCCLs) requiring restoration. Lesions were confirmed as non-carious Class V cervical defects using the Smith and Knight Tooth Wear Index (scores 2-3) to ensure standardized dentin exposure without pulpal involvement.(3) 2. The selected teeth were required to be free from mobility and exhibit normal pulpal and periapical status, confirmed by the absence of spontaneous pain, tenderness to percussion, clinical signs of pulpal necrosis, and periapical radiolucency on periapical radiographs. 3. Participants were required to have at least 20 natural teeth in occlusion, with the selected teeth in functional occlusion, to ensure adequate occlusal stability, uniform distribution of masticatory forces, and standardized functional loading. 4. The cavity configuration had to present an incisal margin located in enamel and a gingival margin located in dentin. To standardize the dentin-to-enamel bonding substrate, only lesions with ≤50% of the cavosurface margin in enamel were included. 5. The cervical cavity margin had to be equigingival or supragingival. 6. Dentin sclerosis was assessed before enrollment by visual inspection and tactile examination using a dental explorer according to the University of North Carolina (UNC) Clinical Dentin Sclerosis Scale (scores 1-4). To standardize the dentin substrate and minimize substrate-related variability, only lesions with sclerosis scores of 1 or 2 were included 7. Caries risk was assessed using the Caries Management by Risk Assessment (CAMBRA) protocol. Participants classified as having moderate caries risk were eligible for inclusion. A limited number of high-risk participants were also accepted provided that the only high-risk criterion present was "three or more carious lesions or restorations within the previous 36 months." 8. Participants had to be willing and able to comply with the study protocol and attend all scheduled follow-up visits. \- Exclusion Criteria: * Participants were excluded if they presented with poor oral hygiene, chronic periodontitis, were undergoing active orthodontic treatment or periodontal surgery, or had xerostomia or were pregnant. Individuals with systemic conditions that could influence oral or periodontal health (e.g., hypertension, diabetes mellitus, malignancy, or other chronic diseases), or those receiving medications known to affect periodontal tissues or wound healing, were also excluded. In addition, participants exhibiting signs of severe parafunctional habits, including clenching or pronounced occlusal wear facets suggestive of bruxism, were not considered eligible for inclusion.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Faculty of Dentistry, Mansoura University

    Al Mansurah, Dakahlia Governorate, 35516, Egypt

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