App aims to boost motivation in schizophrenia patients
NCT ID NCT06067984
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a smartphone app can help reduce negative symptoms of schizophrenia, such as lack of motivation and pleasure. It includes 73 adults and older teens who already completed a previous trial with the same app. Participants use the app for 16 weeks alongside their usual antipsychotic medication, and researchers track changes in symptoms.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- smartphone app (digital therapeutic)
- What this could lead to
- If it works, this could offer a new, non-drug way to help people with schizophrenia feel more motivated and engaged.
- What could go wrong
- This is a small, open-label extension study with no placebo group, so results may be biased. The app is an add-on, not a replacement for medication.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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73 people
The number who actually took part.
- Started
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Sep 2023
- Finished
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Aug 2025
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: A participant will be eligible for entry into the study if all the following criteria are met: * Completed participation in NCT05838625 study within 7 days of the extension study Baseline Visit (Day 1). * Is the sole user of an iPhone with an iPhone operating system (iOS) 14 or greater or a smartphone with an Android operating system (OS) 10 or greater and is willing to download and use the specified Study App required by the protocol. * Is willing and able to receive SMS text messages and push messages on their smartphone. * It is the owner of, and has regular access to, an email address. * Has regular access to the Internet via cellular data plan and/or wi-fi. * Had stable housing during NCT05838625, with no anticipated housing changes during the duration of this study. Exclusion Criteria: A participant will not be eligible for study entry if any of the following criteria are met: * Has not completed the Week 16 Visit (Day 112) in the NCT05838625 study. * Has a positive urine drug screening or participant self-reports use of synthetic cathinones (bath salts), synthetic cannabinoids (K2, Spice), inhalants, amphetamines (including MDMA/ecstasy), phencyclidine (PCP), cocaine, opiates, benzodiazepines, barbiturates, hallucinogens, or parenteral drugs. Participants with a positive urine drug test and/or recreational use of THC will not be excluded from the study at the discretion of the investigator. Participants with a positive urine drug screen (UDS) or self-report who have a valid prescription for barbiturates, benzodiazepines, or opiates will not be excluded from the study at the discretion of the investigator. * Has suicidal ideation or behavior, as assessed by the C-SSRS: 1. Participants with a "yes" response to either Items 4 or 5 on the C-SSRS Suicidal Ideation Item during the NCT05838625 study. 2. Participants with a "yes" response on the C-SSRS Suicidal Behavior Items within the last 6 months (26 weeks) prior to or at the Baseline Visit * Participants who, in the opinion of the investigator, present a serious risk of suicide.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Click Therapeutics
New York, New York, 10013, United States
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Other studies related to the condition(s) this trial covers.
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