Gut check: can fiber supplements boost your microbiome?
NCT ID NCT05906589
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how two types of dietary fiber, psyllium and inulin, affect gut bacteria and related substances in healthy adults over 60. Participants took each fiber or a placebo for two weeks, with breaks in between. The goal was to see if some people respond better to fiber than others, which could help personalize diet advice.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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40 people
The number who actually took part.
- Started
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Sep 2023
- Finished
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Jul 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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60 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * \>60 years old Exclusion Criteria: Medication exclusion criteria: * Oral antibiotic use (within the past 3 months due to impact on gut microbiota). * Anti-coagulants (Warfarin). * Carbamazepine (epilepsy) * Digoxin (heart conditions) * Mesalazine (gut problems) * Regular use of anti-constipation medication/laxatives. Medical exclusion criteria: * Food allergies, self-reported food sensitivity or intolerance. * Type 1 or Type 2 diabetes. * Coeliac disease or gluten intolerance. * Metformin intake. * Bowel obstruction * Muscle weakness of the bowel * Phenylketonuria. Other exclusion criteria: * Anyone with unsuitable veins for blood sampling. * Anyone with chronic constipation (\>3 days without defaecation). * Anyone who is unable to fluently speak, read and understand English.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rowett Institute
Aberdeen, AB25 2ZD, United Kingdom
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