Scientists hunt for fruit and veggie fingerprints in your body
NCT ID NCT05621863
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked for markers in blood and urine that show what fruits and vegetables people eat. 300 adults provided samples before and after eating different amounts of produce. The goal is to create an accurate, objective way to measure diet, replacing unreliable food questionnaires.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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300 people
The number who actually took part.
- Started
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Apr 2023
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Body Mass Index (BMI) 18.5-39.9 kg/m\^2 * Willingness to provide urine and have blood drawn Exclusion Criteria: * Pregnancy or lactation * Allergy or aversion to foods provided in test diet * History of gastrointestinal disorders including the following: 1. Ulcerative colitis or Crohn's disease 2. Celiac sprue 3. Hereditary non-polyposis colorectal cancer (HNPCC) 4. Familial adenomatous polyposis 5. Pancreatic disease 6. Liver disease * Previous gastrointestinal resection or bariatric surgery * Bleeding disorders that preclude blood draws * Recent hospital admissions (past 6 months) for myocardial infarction (MI), cerebrovascular accident (CVA), or congestive heart failure (CHF) * Cardiovascular disease (CVD) under physician guided therapy that is not medically stable * Cancer under radiation or chemotherapy treatment that is active or within 6 months of treatment * Weight change (± 5% in the last 3 months) * Regular alcohol intake of \> 2 drinks/day (equivalent to 720 mL of beer, 240 mL of wine, or 90 mL of spirits), and unwilling to abstain during feeding periods * Use of tobacco and/or marijuana, hookahs, e-cigarettes, or vapes and not willing to abstain during feeding periods * Use of illicit drugs and not willing to abstain during feeding periods * BMI \>40 kg/m\^2 * Regular (daily to weekly) use of over-the-counter (OTC) weight-loss aids and unwilling or unable to stop taking these during feeding periods * Regular (daily to weekly) use of OTC anti-inflammatories and unwilling or unable to stop taking these during feeding periods * Unwilling to stop taking OTC dietary supplements that interfere with the test foods being studied including pills, chewables, liquids or powders for the following (may continue if vitamin supplement is prescribed by a medical doctor): 1. Protein supplements 2. Soy 3. Fiber 4. Flaxseed 5. Fish oil (including cod liver oil) 6. Probiotics 7. Carotenoids 8. Selenium 9. Other antioxidants 10. Other phytochemicals 11. Glucosamine 12. Chondroitin * Oral or IV antibiotic use in the past 6 months (could defer participation until 6 months post-completion of course of antibiotics) * Seated blood pressure \>140/90 mmHg * Fasting clinical lab values outside of the following ranges: 1. Fasting Glucose: 54-125 mg/dL 2. Urea: 6-50 mg/dL 3. Creatinine: 0.4-1.3 mg/dL 4. Estimated Glomerular Filtration Rate (eGFR): \>60 mL/min 5. Sodium: 133-146 mmol/L 6. Alanine Transaminase (ALT): 5-60 U/L 7. Aspartate Aminotransferase (AST): 5-40 U/L 8. Alkaline Phosphatase (ALP): 20-135 U/L 9. Total Bilirubin: 0.0-1.9 mg/dL 10. Total Protein: 5-9.0 g/dL 11. Albumin: 3.5-5.9 d/L 12. Low-density Lipoprotein (LDL) Cholesterol: \<160 mg/dL 13. Triglycerides: \<500 14. White Blood Cells: 3-10.5 Kl/µL 15. Hematocrit: 35-48 g/dL (women), 37.5-49 g/dL (men) * Current use of the following prescription medications: 1. Diuretics 2. Steroids (oral): daily oral any dose within 1 month of study (except for oral contraceptive pills) 3. Opiates: any use within 1 month of study 4. Hypolipidemic agents that affect GI or renal function (ie. fibrates) 5. Hypoglycemic medications other than metformin (ie. insulin, SGLT2 inhibitor, α-glucosidase inhibitor) 6. Psychiatric medications that affect metabolism/renal function (anti-psychotics, lithium) 7. Biologics/immune modulators (ie. rheumatoid arthritis, psoriasis, other rheumatologic/hematologic active disease) 8. Anti-coagulants (coumadin, heparin, Eliquis, etc.) 9. HIV/HAART medications (dyslipidemia inducing) * Inability to freely give informed consent
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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USDA ARS Western Human Nutrition Research Center
Davis, California, 95616, United States
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