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Diesel fumes may harm the Nose's 'Smell Center' – could this link to dementia?

NCT ID NCT07237958

Knowledge-focused Sponsor: Umeå University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study exposed 40 healthy, non-smoking adults to diesel exhaust and clean air to see how pollution affects the olfactory system (the part of the nose that detects smells). Researchers took biopsies from the nose and tested thinking and smell abilities. The goal is to understand if air pollution can trigger changes that might lead to dementia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
diesel exhaust particles
What this could lead to
If it works, this could help explain how air pollution might contribute to dementia, pointing toward prevention strategies.
What could go wrong
This is a small, early study in healthy people, not patients. It only looks at short-term effects, so it may not reflect real-world long-term risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Feb 2019

Finished

May 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy * non-smoker Exclusion Criteria: * Allergic rhinitis * Asthma * Diabetes mellitus * Kidney or liver failure * Angina pectoris or previous ventricular arrhythmia * Systolic blood pressure \>190 mmHg or \<100 mmHg * Previous blood disease * Blood donation in the last three months prior to study start * Previous or ongoing tobacco smoking and exposure to air pollution in the workplace * Absence of informed consent

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Air pollution exposure Alzheimer disease (AD) Dementia Alzheimer type

Contacts and locations

Locations

  • Umeå Univeristy

    Umeå, 90185, Sweden

More trials for these conditions

Other studies related to the condition(s) this trial covers.