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Can a Two-Drug throat spray calm the cough when breathing tubes come out?

NCT ID NCT07832214

NEW Symptom relief Sponsor: Sohag University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers test whether spraying a mix of dexmedetomidine and lidocaine into the throat reduces coughing when a breathing tube is removed after thyroid surgery. The trial enrolls 120 women aged 18 to 65 having elective thyroidectomy under general anesthesia. Participants receive either the combined spray, lidocaine alone, or a saline placebo, and the team measures how often and how severely patients cough during and just after tube removal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A throat spray combining dexmedetomidine with lidocaine
What this could lead to
If it works, this spray could become a simple way to reduce coughing and throat discomfort when breathing tubes come out after surgery.
What could go wrong
This is a single-center study of 120 women having thyroid surgery, so results may not apply to other patients or operations. The spray could fail to beat lidocaine alone, and both drugs can cause side effects such as low blood pressure or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients aged 18-65 years * American Society of Anesthesiologists (ASA) physical status I-II * Scheduled for elective thyroidectomy under general anesthesia with endotracheal intubation * Provided written informed consent Exclusion Criteria: * Known allergy or contraindication to dexmedetomidine, lidocaine, or study medications * Pre-existing cough or respiratory tract infection within 2 weeks * History of chronic cough or reactive airway disease (asthma, COPD) * Significant cardiovascular disease (arrhythmias, uncontrolled hypertension, heart failure) * Hepatic or renal dysfunction (liver enzymes \>2× upper normal limit, creatinine \>1.5 mg/dL) * Pregnancy or breastfeeding * Anticipated difficult airway (Mallampati class III-IV, limited neck extension) * Preoperative use of antitussive medications or opioids * Body mass index \>35 kg/m² * Emergency surgery * Participation in another interventional trial within 30 days

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cough suppression Thyroidectomy

Contacts and locations

Locations

  • Faculty of Medicine, Sohag University

    Sohag, Egypt

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