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New pain combo could cut opioid use after cancer surgery

NCT ID NCT07263165

Symptom relief Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding dexmedetomidine to the standard numbing drug bupivacaine in a specific nerve block can reduce opioid painkiller use and pain intensity after upper abdominal cancer surgery. About 54 adults aged 18-70 scheduled for surgeries like gastrectomy or hepatectomy will be randomly assigned to receive either the combination or bupivacaine alone. The main goal is to see if the combo lowers total opioid consumption in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine added to bupivacaine
What this could lead to
If it works, this could offer better pain control and less reliance on opioids after upper abdominal cancer surgery.
What could go wrong
This is a small, early-phase trial with only 54 participants, so results may not apply broadly. The added drug could also cause side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 18-70 years scheduled for elective upper abdominal cancer surgery (e.g., gastrectomy, hepatectomy, pancreatectomy). * American Society of Anesthesiologists (ASA) physical status I-III. * Body mass index (BMI) between 18-35 kg/m². Exclusion Criteria: * Patient refusal. * Allergy to local anesthetics or dexmedetomidine. * Coagulopathy (INR \>1.5, platelet count \<100,000/mm³). * Infection at the injection site. * Severe cardiopulmonary, renal, or hepatic dysfunction. * Chronic opioid use (\>30 mg morphine equivalents daily for \>3 months). * Pregnancy or lactation.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Opioid consumption, postoperative

How to take part

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  1. The official record

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  2. A doctor treating you

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