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Could a single surgical drug spare seniors from chronic pain?

NCT ID NCT07744308

Knowledge-focused Sponsor: Chinese PLA General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study looks at whether giving dexmedetomidine during major abdominal surgery can reduce the chance of chronic pain three months later in patients aged 65 and older. Researchers will analyze data from over 2,700 older adults who had elective gastrointestinal or liver surgery, comparing those who received the drug with those who did not. The goal is to see if this approach might ease the burden of persistent pain after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine
What this could lead to
If the analysis shows a benefit, it could point toward using dexmedetomidine during surgery to lower the risk of long-term pain in older patients.
What could go wrong
This is a secondary analysis of existing data, not a randomized trial, so it can only suggest associations, not prove cause and effect. Results may be influenced by unmeasured factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

2,754 people

The number who actually took part.

Started

Apr 2020

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study is a secondary analysis based on a multi-center prospective database. We included 2,754 elderly patients who underwent major abdominal surgeries at five medical centers from April 2020 to April 2022. The data were sourced from Perioperative Database of Elderly Patients in China, which is a multi-center prospective study. The main objective of this parent study is to identify the perioperative risk factors for elderly non-cardiac surgery patients and establish a targeted risk prevention and management plan.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 65 years; 2. Underwent elective gastrointestinal and hepatobiliary surgeries. Exclusion Criteria: 1. Patients with ASA grade IV or above; 2. Patients with missing exposure factor data; 3. Patients without postoperative pain assessment data; 4. Patients transferred to the ICU after surgery or who died within 7 days after surgery.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic postoperative pain

Contacts and locations

Locations

  • Department of Anesthesiology, First Medical Center of the People's Liberation Army General Hospital, Beijing, Haidian 100853

    Beijing, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.