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Steroid shot may tune the clock on spinal anesthesia

NCT ID NCT07837674

NEW Symptom relief Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 23, 2026 · Last updated Sep 23, 2026

Summary

Researchers are testing whether a single 8 mg dose of intravenous dexamethasone changes how long sensory and motor block lasts after spinal anesthesia with chloroprocaine. The trial enrolls 60 adults aged 18 to 90 scheduled for lower body surgery under this type of spinal anesthesia. Participants receive either dexamethasone or a saline placebo during the procedure, and the team measures when feeling and movement return.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Intravenous dexamethasone, a steroid given as a single 8 mg dose during spinal anesthesia
What this could lead to
If it works, a single dose of dexamethasone could give surgical teams a simple way to adjust how long a spinal block lasts, helping patients recover feeling and movement sooner after lower body surgery.
What could go wrong
This is a small single-center study of 60 people, so any effect may be modest or may not hold in larger or different surgical groups. Dexamethasone can raise blood sugar and has other steroid-related risks, and it may not change block duration at all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 90 years old * ASA status I to III inclusively * Planned lower body surgery under spinal anesthesia with chloroprocaine * Signed informed consent form Exclusion Criteria: * Contraindication to spinal anesthesia: infection at the puncture site, congenital or acquired coagulopathy * Preexisting neuropathy or nerve block that could interfere with study assessments * Allergy or hypersensitivity to local anesthetics, dexamethasone, or other medications used in the study * Preoperative use of corticosteroids * Patient refusal * Inability to consent * Language barrier, psychiatric, physical, or mental condition making sensory and motor blocks assessment impossible despite prior instruction * Administration of any intrathecal adjuvant (fentanyl, morphine, clonidine, dexmedetomidine, epinephrine, or others) along with chloroprocaine * Perioperative intravenous dexmedetomidine administration * Conversion to general anesthesia * Impossible post-anesthesia care unit assessment: patient still intubated / transfer to intensive care unit, research team constraints, or other reasons * Assessment in the recovery room impossible: medical condition (shock, delirium, major agitation, altered state of consciousness, or other), transfer to the intensive care unit, research team constraints, or other

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prolonged motor block Prolonged sensory block Spinal anesthesia

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Santé Québec - Centre hospitalier de l'Université de Montréal

    Montreal, Quebec, H2X 3E4, Canada

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