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New varnish showdown: can a fluoride coating soothe sensitive teeth?

NCT ID NCT07622043

Symptom relief Sponsor: Ivoclar Vivadent AG Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This study compares two dental varnishes—one with fluoride and one without—to see which better reduces tooth sensitivity. Sixty-six adults with sensitive teeth will have each varnish applied to different teeth and rate their pain over time. The goal is to find a simple, effective treatment for dentin hypersensitivity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fluoride-containing varnish and fluoride-free placebo varnish
What this could lead to
If it works, this could point toward a more effective way to relieve tooth sensitivity using a simple varnish.
What could go wrong
This is a small, early-stage trial with only 66 people. The fluoride-free varnish is a placebo, so the real benefit may be small or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 66 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Informed Consent signed by the subject * Age: 18-65 years * Hypersensitivity assessment scale ≥ Grade 2 in * two non-neighboring teeth in different quadrants * The affected teeth are/have: vital, caries-free, received no restorations within the last month * No change in medication anticipated over the next 3 months (e.g. due to upcoming surgery etc.) Exclusion Criteria: * Contraindications and limitations of the MD as described in the instructions for use. * Known hypersensitivity or allergy to the device material (especially acrylates, mint flavouring) * Pregnant or other vulnerable subjects * Participants with severe systemic disease * Enrolment of employees of the dental clinic of Ivoclar Vivadent AG * Recent change in medication concerning Analgesics, NSAIDs, psychotropic drugs, other medications that may alter pain perception * Intake of analgesics prior to appointment * Professional desensitizing therapy in the last 3 months * Bleaching procedures in the last 4 weeks * Confounding dental conditions at test sites: defective or extensive restorations, abutment teeth for prostheses, recent restorations, pulpitis/periapical pathology. * Current or recent use of desensitizing toothpastes or mouthrinses (i.e. products specifically marketed for the treatment of dentin hypersensitivity) within 4 weeks prior to enrolment

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Conditions

The condition(s) this trial relates to.

dentin sensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dentin desensitizing agents Dentin hypersensitivity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Internal Clinic Ivoclar Vivadent AG

    RECRUITING

    Schaan, 9494, Liechtenstein

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