Brain pacemaker shows promise for rare childhood epilepsy

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Meets the diagnostic criteria for Lennox-Gastaut Syndrome (LGS) based on comprehensive assessment of medical history, seizure semiology, and electroencephalographic (EEG) findings during both ictal and interictal periods; 2. Interictal EEG demonstrates generalized paroxysmal fast activity (GPFA) and slow spike-and-wave (SSW) complexes; 3. Generalized tonic-clonic seizures (GTCs) have been captured in prior video-EEG monitoring, or seizure episodes have been clearly described by reliable eyewitnesses; 4. During the screening or baseline period, the following conditions are met: 1. The patient or caregiver is capable of reliably maintaining a seizure diary; 2. The seizure diary indicates an average of at least 5 seizures per month; 3. The patient is on two or more antiepileptic drugs (AEDs), with a stable treatment regimen (no new add-on or withdrawal of AEDs, excluding temporary rescue medications such as benzodiazepines; dose adjustments are allowed); 5. The patient has been evaluated through a comprehensive presurgical epilepsy workup and is considered unsuitable for, or has declined, resective epilepsy surgery, or has had unsatisfactory outcomes from resective or ablative procedures; 6. Providation of written informed consent, demonstrates adequate compliance with the study protocol, and agrees to participate in this clinical study. Exclusion Criteria: 1. Unable to provide a reliable seizure diary by self or legal guardian; 2. Predominant seizure type is focal impaired awareness seizures; 3. Psychogenic non-epileptic seizures within 12 months; 4. Brain structual abnormalities precluding safe implantation of deep brain stimulator; 5. Conditions associated with increased risk of intraoperative or postoperative bleeding (e.g., coagulopathy), or requirement for long-term oral anticoagulant or antiplatelet therapy; 6. Presence of other severe somatic or internal medical conditions, including significant hepatic or renal dysfunction; 7. Pregnant, or planning to pregnant within 2 years.