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New hope for aggressive leukemia: drug combo aims to wipe out hidden cancer cells

NCT ID NCT06253637

First seen Mar 11, 2026 · Last updated May 23, 2026 · Updated 12 times

Summary

This study tests whether adding the drug daratumumab to standard chemotherapy can completely clear leukemia cells in adults aged 18-65 with very high-risk T-cell acute lymphoblastic leukemia (T-ALL). The main goal is to see if more patients have no detectable cancer after the first round of treatment. About 31 participants will receive daratumumab alongside a pediatric-inspired chemotherapy plan.

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Contacts and locations

Locations

  • Ematologia AOU Careggi

    Florence, Italy

  • Ematologia AOU Policlinico Umberto I

    Roma, Italy

  • Ematologia P.O. Vito Fazzi - Lecce

    Lecce, Italy

Conditions

Explore the condition pages connected to this study.