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New drug duo targets tough cancers with KRAS mutation

NCT ID NCT06166836

First seen Jan 17, 2026 · Last updated May 23, 2026 · Updated 16 times

Summary

This study tests two experimental drugs, D-1553 and IN10018, together in people with advanced solid tumors that have a specific change in the KRAS gene (G12C). The goal is to find the safest and most effective dose and see if the combination can shrink tumors. About 140 adults whose cancer has worsened after standard treatments will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • First Affiliated Hospital of Bengbu Medical College

    Bengbu, China

  • First Affiliated Hospital of Gannan Medical University

    Ganzhou, China

  • Fujian Cancer Hospital

    Fuzhou, China

  • General Hospital Of Eastern Theater Command

    Nanjing, China

  • Henan Cancer Hospital

    Zhengzhou, China

  • Hunan Cancer Hospital

    Changsha, China

  • Renmin Hospital of Wuhan University

    Wuhan, China

  • The first Affiliated Hospital of Zhengzhou University

    Zhengzhou, China

  • Xuzhou Central Hospital

    Xuzhou, China

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang, 310005, China

Conditions

Explore the condition pages connected to this study.