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New pill-and-shot combo targets hard-to-treat cancers with PTEN loss

NCT ID NCT07446049

First seen Mar 05, 2026 · Last updated May 24, 2026 · Updated 7 times

Summary

This study tests a new combination of two drugs (CVL237 tablets and serplulimab injection) in people with advanced solid tumors that have lost or have low levels of a protein called PTEN. The goal is to see if the combo can shrink or control the cancer. About 180 adults aged 18-75 whose cancer has worsened after standard treatments will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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