Can a fully digital smile makeover beat the old way? a trial puts custom implant crowns to the test.
NCT ID NCT07731854
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This trial tests whether a fully digital approach to replacing a single front tooth leads to better-looking results than the standard method. Participants who need a tooth extracted in the visible 'esthetic zone' will be randomly assigned to receive either a custom-designed implant and crown made with digital tools or a conventional implant and crown. The study will compare gum health, tooth appearance, and bone thickness around the implant to see which method looks more natural.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- custom-designed digital implant crown and guided implant placement
- What this could lead to
- If successful, this approach could offer a more predictable and esthetically pleasing way to replace a single front tooth using digital technology.
- What could go wrong
- This is a small, early-stage trial with only 36 participants, so results may not apply to everyone. The procedure is more complex and may not always improve appearance as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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36 people
The number who actually took part.
- Started
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May 2022
- Finished
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Jul 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures 2. Males or females ASA I or II, between 25 to 80 years of age 3. One tooth in the high esthetic region planned for extraction. 4. Patient in good general health as documented by self-assessment. 5. Patients must be committed to the study and must be willing to sign the informed consent. Exclusion Criteria: 1. Any disorder, which in the Investigator's opinion might jeopardise the participant's safety or compliance with the protocol 2. Any prior or concomitant treatment(s) that might jeopardise the participant's safety or that would compromise the integrity of the Trial 3. Participation in an interventional Trial with an investigational medicinal product (IMP) or device 4. Any systemic medical condition that could interfere with the surgical procedure or planned treatment. 5. Immunosuppression, Diabetes, Anticoagulation or Antiaggregatory medication. 6. Current pregnancy or breast feeding/ lactating at the time of recruitment. 7. Radiotherapy or Chemotherapy in head and neck area. 8. Intravenous and oral bisphosphonate therapy. 9. Smokers 10. Unwillingness to return for the follow-up examination. 11. Conditions or circumstances, in the opinion of the investigator, which could represent a general contra-indication for surgical procedure or would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, or unrealistic expectations. 12. Presence of osseous pathologies, that may interfere with normal wound healing. 13. Presence of oral lesions (such as ulceration, malignancy). 14. Local inflammation, including untreated periodontitis. 15. Patients with inadequate oral hygiene or unmotivated for adequate home care
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UZ Gent
Ghent, Oost-Vlaanderen, 9000, Belgium
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UZLeuven, Campus St. Raphaël, Department Oral Health Sciences, Periodontology
Leuven, Vlaams Brabant, 3000, Belgium
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