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New eczema cream studied in kids and adults – could reduce steroid use?

NCT ID NCT07014007

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a cream called RV4421B-EV0407, a medical device already sold in some countries, for mild to moderate atopic dermatitis (eczema). It includes 105 participants from 3 months old to adults, with diverse skin types. The cream is used alone or with steroid creams for up to 12 weeks. Researchers are checking how well the skin tolerates it and if it helps control eczema.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
RV4421B-EV0407 cream (medical device)
What this could lead to
If successful, this could provide a well-tolerated, steroid-sparing option for managing eczema symptoms across diverse skin types and ages.
What could go wrong
This is an early-phase, open-label study with no placebo group, so results may be biased. The cream is already marketed, but long-term efficacy and safety in diverse populations are still being confirmed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 105 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

3 months and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Male or female, with any phototype according to Fitzpatrick classification aged: * Group 1 (infants group): from 3 months to 23 months old included * Group 2 (children group): from 24 months to 12 years old included * Group 3 (teenagers \& adults group): from 13 years old * Subject with a diagnosis of atopic dermatitis according to the U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis (Williams HC, Burney PG, et al.). * Subject with studied areas (lesions and prevailing xerotic areas) limited up to 30% of the body surface area * Subject with mild to moderate Atopic Dermatitis Criteria related to treatments and/or products: • Topical corticosteroids treatments (following international treatment guidelines for each age sub-group and including investigator agreement) applied on AD lesions areas since 1 to 5 days before the inclusion and ongoing at the time of inclusion. \* \*The investigator will be authorized to adjust the treatment during the study. Exclusion criteria: Criteria related to the skin condition or the disease: * Infant with Atopic Dermatitis lesions or prevailing xerotic areas located on the diaper (groups 1 \& 2) * Subject with history of allergy or intolerance to any of the study product(s) ingredients or material used for the research * Subject having any other dermatologic condition than Atopic Dermatitis, or characteristics (like tattoo…) on the studied areas liable to interfere with the study assessments * Subject having a dermatological condition, an acute, chronic or progressive disease or history of disease liable to interfere with the study data or considered by the Investigator hazardous for the subject or incompatible with the study requirements * Knowledge of Acquired Immunodeficiency Syndrome or Infectious (acute or chronic) Criteria related to treatments and/or products: * Systemic biological immunosuppressive treatment established or modified within 12 weeks before the inclusion or planned to be started during the study * Phototherapy performed within 4 weeks before the inclusion visit or planned to be started during the study * Systemic non-biological immunosuppressive treatment established or modified within 4 weeks before the inclusion or ongoing or planned to be started during the study * Systemic corticosteroids treatment established or modified within 4 weeks before the inclusion or ongoing or planned to be started during the study * Systemic antibiotics for dermatological purposes treatment established or modified within 2 weeks before the inclusion or ongoing or planned to be started during the study * Systemic antihistaminic treatment established or modified within 2 weeks before the inclusion * Topical treatments (immunomodulators (TIMs), non-steroidal anti-inflammatory, antihistaminic, antibiotics for dermatological purposes or antiseptics) applied on studied areas within 1 week before the inclusion or ongoing or planned to be started during the study * Any other topical treatment or product applied on studied areas incompatible with the study or liable to interfere with the study assessments according to the investigator, in the weeks prior to the inclusion visit, ongoing or planned to be started during the study * Skin care product (including moisturizer) applied on the whole body between the evening before the visit and the inclusion. * Water and/or any cleansing product, applied on the whole body within 4 hours before the inclusion visit. If there is no studied area on the face, the subject is allowed to do a light face wash without time restriction (especially in the morning of the visit). * Subject who plans to modify his/her usual moisturizer (allowed outside studied areas) and/or care habits during the study Treatment of the mother if the subject of group 1 and 2 is breastfed: * Systemic biological immunosuppressive treatment established or modified within 12 weeks before the inclusion or planned to be started during the study * Systemic non-biological immunosuppressive treatment established or modified within 4 weeks before the inclusion or planned to be started during the study * Systemic corticosteroids established or modified within 2 weeks before the inclusion or planned to be started during the study * Systemic antihistaminic established or modified within 2 weeks before the inclusion * Systemic antibiotics for dermatological purposes established or modified within 1 week before the inclusion or planned to be started during the study

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Conditions

The condition(s) this trial relates to.

atopic eczema dermatitis Eczema Erythema Paresthesia Pruritus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Insight Research Ltd

    RECRUITING

    Quatre Bornes, Mauritius, 742CU001, Mauritius

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