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Brain scans could help predict who wakes from coma

NCT ID NCT03308305

Knowledge-focused Sponsor: Rijnstate Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at whether MRI scans can help doctors predict if a coma patient will recover brain function after a cardiac arrest. Researchers followed 94 comatose patients in the ICU, scanning their brains at different times. The goal was to improve how doctors identify patients who may or may not regain consciousness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to more accurate predictions of which coma patients may wake up, helping doctors make better treatment decisions.
What could go wrong
This is an observational study with only 94 participants, so results may not apply to all patients. It aims to improve understanding, not test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

94 people

The number who actually took part.

Started

Jun 2018

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of one hundred adult, comatose patients, successfully resuscitated from cardiac arrest. Generally, these patients are predominantly male and approximately 60-65 years of age. The patients are by definition at least temporarily incapacitated.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Comatose, defined as Glasgow Coma Score ≤ 8 * Age ≥ 18 years * Cardiac arrest with a presumed cardiac cause of the arrest or caused by pulmonary embolism * Admission to ICU Exclusion Criteria: * Pregnancy * Life expectancy \< 24 hours * Absence of written informed consent (by a legal representative) * Pre-existing dependency in daily living, defined as CPC score 3 or 4 * Any known progressive brain illness, such as a brain tumor or neurodegenerative disease. * Known contra-indication for MRI

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Conditions

The condition(s) this trial relates to.

cardiac arrest Coma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-anoxic coma Postanoxic enchephalopathie

Contacts and locations

Locations

  • Maastricht University Medical Center

    Maastricht, Netherlands

  • Radboud University Medical Centre

    Nijmegen, Gelderland, Netherlands

  • Rijnstate Hospital

    Arnhem, Gelderland, 6815 AD, Netherlands