Can a partner's support ease PTSD and drinking? new VA study aims to find out.
NCT ID NCT07388654
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tests a brief couples therapy for 80 Veterans with PTSD and alcohol use disorder. Veterans receive individual treatment while attending 3-4 sessions with their romantic partner. The goal is to see if involving loved ones improves treatment satisfaction and reduces symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2027
An estimate. Start dates often move.
- Expected to finish
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Feb 2031
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Inclusion criteria for Veterans and Significant Others: * Any gender or sexual identity; any race or ethnicity * Married, cohabiting for at least 6 months, or in a committed relationship for at least 6 months and both partners are willing to participate. * The Veteran meets current or past-year DSM-5 diagnostic status for both PTSD (assessed via CAPS-5) and AUD (assessed via the Quick Structured Clinical Interview for DSM-5) * Concurrent substance use disorders are acceptable provided that alcohol is the Veteran's primary substance of choice * Must demonstrate cognitive functioning sufficient to provide informed consent and participate accurately (=\>26 on the Mini-Mental State Exam \[MMSE\]) * Participants taking psychotropic medications will be required to be maintained on a stable dose for at least 4 weeks before study initiation * Not currently enrolled in couple therapy Additional inclusion criteria for the Veteran patient: * U.S. military Veteran * Enrolled, or is willing to become enrolled, in VA healthcare * Not attending trauma-focused therapy during the intervention period Exclusion Criteria: * History of moderate, severe, or unilateral violence in the relationship in the past year as measured by the CTS-2 * Either partner demonstrates a need for a higher level of care as assessed by the Quick Structured Clinical Interview for DSM-5 Disorders (QuickSCID) * i.e., history of or current psychotic or bipolar disorders, current severe drug use disorder, or concerns about alcohol withdrawal as demonstrated by a score \>8 on the CIWA-Ar) * Either partner reports current suicidal or homicidal ideation and intent or prior intent or attempt in the past 6 months as assessed by the CSSRS and PHQ-9 item 9 * The Veteran's SO cannot have substance use problems as indicated by a score \< 8 on the AUDIT and QuickSCID
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, South Carolina, 29401-5703, United States