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Smoke tree mouthwash takes on bad breath in braces

NCT ID NCT07254819

Symptom relief Sponsor: University of Athens Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a mouthwash made from the smoke tree (Cotinus Coggygria) to see if it could reduce bad breath and improve oral hygiene in 30 teenagers with braces. Participants used the mouthwash or a placebo twice daily for 14 days. Researchers measured breath sulfur compounds and plaque levels to assess results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cotinus Coggygria (smoke tree) mouthwash
What this could lead to
If it works, this could offer a natural mouthwash option to reduce bad breath and improve gum health for teens with braces.
What could go wrong
This is a small, completed trial with only 30 participants, so results may not apply to everyone. The effect may be modest and not a replacement for regular oral care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Dec 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 18 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients eligible for the trial must comply with all of the following at randomization: • Age between 13 and 18 years for the group with conventional orthodontic appliances. This age group represents the majority of patients seeking orthodontic treatment and is homogeneous regarding occupational status (high-school and lyceum students in Greece). Younger patients might present with cooperation problems. * Good general health. * Orthodontic fixed labial appliances on the maxillary and mandibular arch, brackets at least on 20 teeth for more than 4 months before enrollment and estimated duration of the treatment more than 1 month, bands on the first molars, extraction cases patients could be enrolled at least two months after the last extraction. * Total initial VSCs levels above the baseline level of 150ppb. Exclusion Criteria: Patients will be excluded for any of the following reasons: * Active caries * Periodontitis * Dental fluorosis / dysplasia of the teeth * Syndromes, mental disabilities and craniofacial deformities * Smoking or use of other tobacco products * Allergy to Cotinus Coggygria (Smoke tree) * Antibiotics during the last 2 months * Chlorhexidine or other mouthwash use in the previous 3 weeks * Participation in other trials

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Conditions

The condition(s) this trial relates to.

Halitosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Halitosis Orthodontic appliance complication

Contacts and locations

Locations

  • School of Dentistry

    Athens, Attica, 11527, Greece

More trials for these conditions

Other studies related to the condition(s) this trial covers.