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New air bubble technique may help treat thin corneas in keratoconus

NCT ID NCT07426029

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a modified version of corneal collagen cross-linking, a procedure to strengthen the cornea, in 39 people with keratoconus who had thin corneas. Before the standard treatment, doctors added a small air bubble into the cornea to protect the inner layer. The goal was to see if this approach was both effective and safe for these patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

39 people

The number who actually took part.

Started

Oct 2022

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

17 to 33 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Progressive KC proven by clinical examination, tomography, and pachymetry * Thinnest corneal location thickness between 390 to 450 microns Exclusion Criteria: * Previous ocular Trauma or Surgery. * History of herpetic eye disease * Central corneal scarring * Cornea guttata * Ocular surface disease and dry eye disease * Vernal and atopic keratoconjunctivitis * Cataract * Glaucoma, intraocular pressure less than 10 or more than 21 mmHg * Posterior segment abnormalities * Nystagmus or other conditions that interfere with patient's fixation * Diabetes mellitus * pregnancy * Collagen vascular disease, autoimmune disease and patients receiving immunosuppressive therapy

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Conditions

The condition(s) this trial relates to.

keratoconus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Keratoconus

Contacts and locations

Locations

  • Department of Ophthalmology-Faculty of Medicine-Cairo University

    Giza, Giza Governorate, 11562, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.