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New study tests gentler surgery for pregnancy loss after IVF

NCT ID NCT07143578

Disease control Sponsor: Assaf-Harofeh Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two surgical methods—hysteroscopy and suction curettage—for treating early pregnancy loss in women who conceived through IVF. The goal is to see which method causes fewer uterine scars (adhesions) and leads to better future fertility. Fifty participants will be randomly assigned to one of the two procedures, and scarring will be checked with a camera test 6-8 weeks later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Operative hysteroscopy using tissue removal device; suction curettage using plastic suction curette
What this could lead to
If hysteroscopy works better, it could reduce scarring in the uterus and improve chances of future pregnancy for women who have had an early pregnancy loss after IVF.
What could go wrong
This is a small, early-stage study with only 50 participants, so results may not apply to everyone. Hysteroscopy takes longer and may not always prevent adhesions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosis of early pregnancy loss up to 10 weeks' gestation, based on last menstrual period or ultrasound. 2. Pregnancy conceived through assisted reproductive techniques (in vitro fertilization, IVF). 3. Ability to provide informed consent, and proficiency in reading and writing Hebrew. Exclusion Criteria: 1. Heavy vaginal bleeding or diagnosis of incomplete abortion. 2. Signs of infection and/or suspicion of septic abortion 3. Known uterine anomalies- including septate, bicornuate, unicornuate, or didelphys uterus. 4. Prior medical or surgical treatment during the current pregnancy 5. History of intrauterine adhesions 6. History of ≥ 3 prior miscarriages. 7. History of ≥ 3 prior cesarean sections. 8. History of myomectomy via abdominal or hysteroscopic approach.

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Conditions

The condition(s) this trial relates to.

Abortion, Missed Abortion, Spontaneous gynatresia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Early abortion Pregnancy loss, early

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shamir Medical Center

    RECRUITING

    Be’er Ya‘aqov, 70200, Israel

  • Sheba Medical Center, Tel Hashomer

    ACTIVE_NOT_RECRUITING

    Ramat Gan, 52621, Israel

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