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New drug combo may speed up miscarriage care

NCT ID NCT05304273

Disease control Sponsor: Calcutta National Medical College and Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two different drug combinations to end a non-viable pregnancy in the first trimester. One group received the standard treatment (mifepristone plus misoprostol), while the other received letrozole plus misoprostol. The goal was to see which combination works faster and more completely, potentially offering a better option for women experiencing early miscarriage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

120 people

The number who actually took part.

Started

May 2022

Finished

Oct 2024

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA : * Women older than 18years who will give consent regarding medical management of missed abortion * First trimester pregnancy (gestational age less than equal to 12weeks) with missed abortion confirmed by ultrasonography * Hemoglobin level more than 12g/dl. To improve sample size later hemoglobin level 10 gm% or more was considered and EC was informed on 5.10.2022 about this minor change in the study design. EXCLUSION CRITERIA : * Hemodynamically unstable patient * Abnormalities in blood tests including complete blood count (CBC), prothrombin time(PT), internationalised normalized ratio(INR) and fibrinogen * History or clinical evidence of any thromboembolic impairment or deep venous thrombosis * Having intra-uterine device * Present or previous use of corticosteroids * History of any malignancy * Existing cardiovascular disease contraindicating misoprostol

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Conditions

The condition(s) this trial relates to.

Abortion, Spontaneous

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Miscarriage

Contacts and locations

Locations

  • Calcutta National Medical College and Hospital

    Kolkata, West Bengal, 700014, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.