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Home vs. clinic: which lymphedema therapy works best for cancer survivors?

NCT ID NCT05182229

Symptom relief Sponsor: Abramson Cancer Center at Penn Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two approaches to treating lymphedema (swelling) in people who have had head and neck cancer. One group gets all their therapy in a clinic, while the other starts with a few in-person sessions and then continues via video calls at home. The goal is to see if the home-based method is just as effective at reducing swelling, easing symptoms, and improving daily function. The trial involves 240 survivors who are within two years of finishing cancer treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
complete decongestive therapy (CDT)
What this could lead to
If successful, this could show that a home-based hybrid approach works as well as clinic visits, making lymphedema care more convenient and accessible for survivors.
What could go wrong
This is a mid-sized trial comparing two existing treatments, not testing a new drug. The home-based method may be less effective for some patients, and results may not apply to everyone with lymphedema.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

240 people

The number who actually took part.

Started

Mar 2022

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \>18 years of age * \<=24 months post-HNC treatment * Diagnosis of head and neck lymphedema and referral by their oncology providers * Able to perform self-manual lymphatic drainage * Having an electronic device (a computer, tablet, iPad, laptop, or smartphone) and internet access at home Exclusion Criteria: * Active infection in soft tissues in the head and neck region * History of moderate or severe carotid artery occlusion * Significantly severe lymphedema (e.g., severe periorbital swelling) * Conditions impacting the safe delivery of lymphedema therapy

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Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms lymphedema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck cancer Lymphedema

Contacts and locations

Locations

  • Asplundh Cancer Pavilion Jefferson Health

    Willow Grove, Pennsylvania, 19090, United States

  • Jefferson Cherry Hospital Jefferson Health

    Cherry Hill, New Jersey, 08002, United States

  • Jefferson Health

    Philadelphia, Pennsylvania, 19107, United States

  • Jefferson Torresdale Hospital Jefferson Health

    Philadelphia, Pennsylvania, 19114, United States

  • Temple University Hospital and Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19140, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

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