Ultrasound showdown: which filler works best for cheek volume?
NCT ID NCT05622851
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compared two hyaluronic acid fillers, Restylane Contour and Juvederm Voluma, for correcting midface volume loss in 11 participants. Using ultrasound and 3D imaging, researchers looked at how the fillers behaved under the skin and how much volume they added. The goal was to see which filler might be better for restoring cheek fullness.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hyaluronic acid dermal fillers (Restylane Contour and Juvederm Voluma)
- What this could lead to
- If successful, this could help doctors choose the best filler for midface volume loss based on how it behaves under the skin.
- What could go wrong
- This is a very small study (11 people) comparing two existing fillers, so results may not apply to everyone. It does not test new treatments or long-term safety.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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11 people
The number who actually took part.
- Started
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Jul 2022
- Finished
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Dec 2023
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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22 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subject with midface volume loss and contour deficiency * Ability of giving consent for participation in the study * Agreement to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments Exclusion Criteria: * History of allergy or hypersensitivity to lidocaine and/or injectable hyaluronic acid * Previous permanent or semi-permanent implant in proposed treatment area * Previous biodegradable tissue augmentation therapy in the proposed treatment area within 12 months prior to the baseline visit * History of other facial treatment/procedure at the study area (midface) in the previous 6 months that would potentially interfere with study injections (e.g., facial surgery, oral surgery, resurfacing, mesotherapy, lipolytic injections, botulinum toxin injections)
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Aesthetic Clinique
Santa Rosa Beach, Florida, 32459, United States
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