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New drug cocktail targets tough lung cancer

NCT ID NCT03333343

First seen Jan 05, 2026 · Last updated May 24, 2026 · Updated 23 times

Summary

This study tests the safety and early effectiveness of adding another drug (INC280, trametinib, ribociclib, gefitinib, or LXH254) to EGF816 for adults with advanced EGFR-mutant non-small cell lung cancer. About 105 participants will receive one of these combinations. The goal is to find tolerable doses and see if the combinations help control the cancer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Novartis Investigative Site

    Toronto, Ontario, M5G 2M9, Canada

  • Novartis Investigative Site

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Novartis Investigative Site

    Essen, 45147, Germany

  • Novartis Investigative Site

    Hong Kong, 999077, Hong Kong

  • Novartis Investigative Site

    Ancona, AN, 60126, Italy

  • Novartis Investigative Site

    Milan, MI, 20162, Italy

  • Novartis Investigative Site

    Rozzano, MI, 20089, Italy

  • Novartis Investigative Site

    Singapore, 119074, Singapore

  • Novartis Investigative Site

    Singapore, 168583, Singapore

  • Novartis Investigative Site

    Tainan, 704302, Taiwan

  • Novartis Investigative Site

    Taipei, 10002, Taiwan

Conditions

Explore the condition pages connected to this study.