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New combo therapy shows promise for Tough-to-Treat cancers

NCT ID NCT05155033

First seen Jan 27, 2026 · Last updated Apr 29, 2026 · Updated 9 times

Summary

This study tests whether combining two drugs—pembrolizumab (an immunotherapy) and aldesleukin (a protein that boosts immune cells)—can shrink tumors in people with advanced melanoma or kidney cancer that has not responded to standard treatments. About 78 adults will receive the drugs through an IV during two short hospital stays. The goal is to see if the combination works better than either drug alone. Participants will be followed for up to 5 years to monitor safety and cancer progression.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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