Could a contact Lens-Like shield soothe scratched eyes?
NCT ID NCT07225699
First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times
Summary
This study tests whether a special collagen shield placed on the eye can reduce pain from a scratched cornea (corneal abrasion) in adults visiting the emergency department. Sixty participants will be randomly assigned to receive either the collagen shield or a fake shield, along with standard pain and antibiotic drops. Researchers will measure pain levels at 4, 24, and 72 hours, as well as how much pain medication is used.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- collagen corneal shield (device)
- What this could lead to
- If it works, this could provide a simple, non-drug way to ease pain from scratched corneas in the ER.
- What could go wrong
- This is a small, early-stage trial with only 60 people. The sham control may also show benefit, and the device might not reduce pain more than standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Nov 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Each of the following criteria must be met for study participation: 1. Male or female, age 18 or older at the time of study enrollment. 2. Corneal abrasion in one eye. 3. Willingness to sign the IRB-approved informed consent form (ICF) for study participation. 4. Availability, willingness, and sufficient cognitive awareness to return for study-required visits and comply with examination procedures. Exclusion Criteria: Patient candidates presenting any of the following characteristics will not be eligible for study participation: <!-- --> 1. Corneal abrasion in both eyes. 2. Allergy to moxifloxacin or other fluoroquinolone antibiotics. 3. Allergy to ibuprofen or other non-steroidal anti-inflammatory drugs. 4. History of neurotrophic cornea for any reason, in the study eye. 5. History of medical conditions known to cause decreased corneal sensation in the study eye including but not limited to HSV, HZO, and diabetes. 6. History of extraocular surgical procedures known to cause decreased corneal sensation in the study eye, including but not limited to trigeminal nerve clamp. 7. Any anterior segment pathology in the study eye that could significantly affect corneal wound healing (e.g. aniridia, clinically significant corneal dystrophies \[ABMD\], etc.) 8. Any visually significant intraocular media opacity other than corneal abrasion in the study eye (as determined by the investigator). Such opacities might include corneal scar or vitreous hemorrhage. 9. History of any clinically significant retinal pathology or ocular diagnosis in the study eye that could, in the investigator's best judgement, alter or limit visual acuity (e.g. ischemic disease, macular degeneration, retinal detachment, optic neuropathy, amblyopia, strabismus, aniridia, epiretinal membrane, etc.). 10. History of uveitis in either eye. 11. History of intraocular or corneal surgery in the study eye besides laser peripheral iridotomy (LPI), retinal barrier laser. 12. Current ocular infection in the study eye. 13. Presence of uncontrolled systemic disease that could limit capacity to sign consent or comply with treatment schedule (e.g. mental illness, dementia, etc.). 14. Unsuitable for study participation for any other reason, as determined by the Investigator's clinical judgement
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.