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Collagen wrap may boost bone repair in implant gum disease

NCT ID NCT07478978

Disease control Sponsor: Ondokuz Mayıs University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding a collagen membrane to a bone graft helps treat peri-implantitis, a serious gum infection around dental implants. 44 adults with bone loss around implants received either the graft alone or the graft plus a collagen cover. Researchers measured gum pocket depth, bleeding, and bone levels to see if the membrane improves healing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
collagen membrane and bone allograft
What this could lead to
If successful, adding a collagen membrane could improve bone healing and reduce infection around dental implants.
What could go wrong
This is a small, completed study with 44 people, so results may not apply to everyone. The benefit of the membrane may be small or not significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

44 people

The number who actually took part.

Started

Dec 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with peri-implantitis characterized by bleeding and/or suppuration on probing and increased probing depth around dental implants. * Presence of circumferential intrabony peri-implant defects requiring reconstructive surgical treatment. * Patients aged 18 years or older. * Presence of functioning dental implants in the oral cavity. * Patients who are able and willing to attend follow-up visits and provide informed consent. Exclusion Criteria: * Patients with uncontrolled systemic diseases that could affect wound healing. * Use of antibiotics or anti-inflammatory drugs within the last 3 months. * Pregnancy or lactation. * Heavy smoking habits. * Poor oral hygiene or lack of compliance with periodontal maintenance therapy. * Previous surgical treatment for peri-implantitis at the study site.

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Biochemical markers Guided bone regeneration Peri-implantitis

Contacts and locations

Locations

  • Ondokuz Mayıs University Faculty of Dentistry

    Samsun, Atakum, 55200, Turkey (Türkiye)

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