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Why some ICU survivors recover mentally better than others: scientists investigate

NCT ID NCT07659431

Knowledge-focused Sponsor: Corporacion Parc Tauli Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why some people recover their thinking and emotional skills better than others after a serious illness requiring intensive care. Researchers will follow 114 adults admitted to ICUs in Spain, collecting blood samples and testing memory, attention, and mood at discharge and up to a year later. The goal is to understand how factors like cognitive reserve, inflammation, and genetics influence recovery, which could lead to better support for survivors.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help identify patients at risk for long-term cognitive problems after ICU stays and guide personalized recovery plans.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test any therapy. The findings may not apply to all ICU survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 114 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Critically ill patients admitted to the medical / post-surgical ICU of the Parc Tauli Hospital (Sabadell, Spain), and to the Hospital Universitario Central de Asturias.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (≥18 years) * Admitted to a medical-surgical ICU or cardiac ICU for causes of critical illness (e.g., acute pulmonary oedema, myocardial infarction, aortic dissection) * With or without the need for invasive mechanical ventilation * With an expected ICU stay of ≥48 hours * Resident in Catalonia or the Principality of Asturias * Who speak Catalan and/or Spanish * Who are able to provide informed consent personally or through an authorised representative (e.g., a family member) Exclusion Criteria: * Non-authorisation by the patient and/or relatives for inclusion in the study * Patients admitted to a neurocritical ICU * History of severe neurological disease (including dementia or focal brain injury with functional and cognitive impairment) prior to ICU admission * History of severe psychiatric disorders (schizophrenia, bipolar disorder, major depressive disorder) * Intellectual disability (IQ \<80) or other neurodevelopmental disorders, such as autism spectrum disorder * Patients who develop secondary complications (e.g., infections, stroke, traumatic brain injury, or other non-transient acquired brain injury) after ICU discharge that may compromise the results of emotional and neuropsychological evaluations during the recovery phase * Moderate to severe cognitive impairment (Short-IQCODE \>57) preventing independent participation in telemedicine or face-to-face follow-up * Readmission to the ICU within 12 months after ICU discharge * Language barrier (non-Spanish- and/or non-Catalan-speaking patients) * Patients with a life expectancy \<1 year or not eligible for active treatment measures

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Critical Illness postintensive care syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Post-intensive care syndrome (PICS)

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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More trials for these conditions

Other studies related to the condition(s) this trial covers.