Coenzyme Q10 tested as a possible remedy for train derailment symptoms
NCT ID NCT06962657
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether the supplement coenzyme Q10 can ease symptoms like fatigue and pain in people affected by the 2023 East Palestine, Ohio train derailment. Twenty participants will take either CoQ10 or a placebo for three months, then switch. The goal is not to prove benefit but to gather data for a future larger trial.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Coenzyme Q10 (ubiquinone) 100 mg oral soft gel
- What this could lead to
- If it works, this could point toward a way to reduce symptoms and improve quality of life for people exposed to toxic chemicals.
- What could go wrong
- This is a very small pilot study (20 people) not designed to prove benefit—only to see if a larger trial is worth doing. Results may not apply to others.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * On Feb. 3, 2023, lived within 10 miles of the East Palestine, OH train derailment (closer in will receive preference). Others who were in the area for toxin mitigation and other reasons and show compatible symptoms will also be eligible. * Meets Kansas symptom criteria for multi-symptom illness - originally defined for Gulf War Illness (has persistent symptoms, lasting greater than six months, that are of \>mild severity in at least three of the six domains of fatigue/sleep, pain, neurological/cognitive/mood, gastrointestinal, respiratory and dermatologic). At least some symptoms must be new or worsened since the derailment. * Access to internet and smart phone or computer for remote Qualtrics survey participation. * Willing to perform the stipulated study elements. * Took ≥80% of run-in soft gels. Exclusion Criteria: * Anticipated move from the area or other anticipated obstacle to participating for study duration. * Participating in another clinical trial. * Has a pre-existing health condition expected to produce significant and variable fluctuating symptoms (e.g. chronic infection and/or active cancer other than non-melanoma skin cancer). * Contraindications to CoQ10, such as use of coumadin (although an interaction with CoQ10 is controversial).
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Get notified about this study
Sign up to get updates when this study changes or when new studies for Toxicant induced chronic multisymptom illness and associated symptoms and comorbidities are added.
Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
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Genom att skicka in godkänner du våra Användarvillkor
Locations
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UC San Diego
La Jolla, California, 92093, United States
Contact Email: •••••@•••••