Fingerprint sweat could replace oral swabs for drug testing
NCT ID NCT07755267
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This study tests whether codeine can be detected in fingerprint sweat as accurately as in oral fluid. Forty healthy adults will receive two doses of codeine, and researchers will compare the results from both sample types. The goal is to find the best cutoff level for fingerprint sweat to match oral fluid testing, potentially enabling a less invasive drug screening method.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- codeine phosphate tablets
- What this could lead to
- If successful, this could lead to a non-invasive fingerprint sweat test for opiate screening, offering a quicker and easier alternative to oral fluid testing.
- What could go wrong
- This is a small, early-stage study in healthy volunteers, so results may not apply to real-world drug testing. The fingerprint method is experimental and may not match oral fluid accuracy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
43 people
The number who actually took part.
- Started
-
Jan 2026
- Finished
-
Feb 2026
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Subjects will be selected from non-institutionalized persons consisting of members of the community at large.
- Ages
-
18 to 55 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Informed of the nature of the study, agreed to, and able to read, review, and sign the informed consent document prior to dosing. The informed consent document will be written in English; therefore, the subject must have the ability to read and communicate in English. 2. Completed the screening process within 30 days prior to dosing. Subjects screened as a part of an IRB-approved General Screening Protocol at the clinical research site may be included in this study without additional screening procedures provided all the required screening procedures have been performed within 30 days prior to dosing. 3. Healthy male and non-pregnant female subjects between ages 18 and 55, inclusive, at the time of dosing. 4. Body mass index (BMI) between 18.0 kg/m2 to 32.0 kg/m2, inclusive, and weigh at least 60 kg. 5. Judged by the Investigator and/or designee to be in good health as documented by the medical history, physical examination (including but may not be limited to an evaluation of the cardiovascular, gastrointestinal, respiratory and central nervous systems), vital sign assessments along with oxygen saturation, 12-lead electrocardiogram (ECG), clinical laboratory assessments, and by general observations. Any abnormalities or deviations outside the normal ranges for any of clinical testing (laboratory tests, ECG, etc.) can be repeated at the discretion of the Investigator and/or designee and judged to be not clinically significant for study participation. Any abnormalities or deviations outside the normal range for vital signs can be repeated by clinical staff and judged to be not clinically significant for study participation. 6. Subjects with glomerular filtration rate (GFR) of greater than or equal to 60. 7. Females of childbearing potential must be willing to practice an acceptable form of contraception, and have a negative serum pregnancy test at screening and a negative urine pregnancy test on admission to the treatment phase of the study. 8. Males must agree to practice an acceptable form of contraception. Exclusion Criteria: 1. More than three digits absent from the hands due to congenital or accidental cause(s). 2. Reports receiving any investigational drug/product within 30 days prior to dosing. 3. Reports any personal history of substance abuse (including drug/alcohol abuse or addiction) or mental illness (e.g. major depression) within one year prior to screening visit. 4. Reports any presence or history of a clinically significant disorder involving the cardiovascular, respiratory, renal, urologic, gastrointestinal, hepatic, immunologic, hematologic, endocrine, or neurologic system(s) or psychiatric disease as determined by the Investigator. 5. Presence of any clinically significant results from laboratory tests, vital signs assessments, as judged by the Investigator. 6. Demonstrates a reactive screen for hepatitis B surface antigen, hepatitis C antibody, or HIV antibody. 7. Reports a clinically significant illness during the 30 days prior to dosing (as determined by the Investigator). 8. Reports a history of allergic response(s) to opiates, naltrexone or related drugs. 9. Reports hypersensitivity to bisulfites. 10. Reports history of respiratory depression (e.g., sleep apnea). 11. Current severe hypotension (i.e., systolic blood pressure \<90 mmHg). 12. Reports current presence of acute bronchial asthma/ upper airway obstruction. 13. If subject reports a history of clinically significant allergies, including food or drug allergies, as judged by the Investigator. 14. Reports history/current condition of adrenal insufficiency. 15. Reports history/current condition of renal disease. 16. Reports a history of smoking within previous six months. 17. Report history/current condition of seizures, increased intracranial pressure, brain tumor, head injuries or impaired consciousness. 18. Reports known or suspected gastrointestinal obstruction including, paralytic ileus. 19. Reports difficulty fasting or consuming standardized meals. 20. Demonstrates a positive pregnancy screen (females only). 21. If, in the opinion of the Investigator, the subject is not suitable for the study.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cliantha Research
Mississauga, Ontario, L4W 1V7, Canada
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