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Vaping lung risks under the microscope: new study recruits 500 canadians

NCT ID NCT06819969

Knowledge-focused Sponsor: University of British Columbia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

The CLOUD study is recruiting 500 Canadians aged 12 and older to understand how vaping may harm lungs over time. Researchers will use advanced breathing tests, exercise tests, and imaging to detect early lung damage that standard tests might miss. Participants include both vapers and non-vapers for comparison. This study aims to provide clear information on the health consequences of vaping.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal early signs of lung damage from vaping, helping users make informed health decisions.
What could go wrong
This is an observational study, not a treatment trial. It may not prove cause and effect, and results may take years to impact practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will enroll both adolescent (ages ≥12 and \<19 years) and adult (≥19 years) e-cigarette and non-e-cigarette users in six academic hospital centres across Canada.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adolescent arm: * Aged ≥12 and \<19 years old * Either 1) use neither combustible cigarettes nor e-cigarettes or 2) use e-cigarettes exclusively Adult arm: * Aged ≥19 years old * Fall into one of the following categories: 1) use neither combustible cigarettes nor e-cigarettes; 2) use combustible cigarettes exclusively, never using e-cigarettes; 3) use e-cigarettes exclusively, never using combustible cigarettes; or 4) use both combustible cigarettes and e-cigarettes currently Exclusion Criteria: Adolescent arm: * Contraindication to pulmonary function testing and cardiopulmonary exercise testing * Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of \>1 joint-year * Have smoked combustible cigarettes within the last 6 months * Have a physician-diagnosed chronic lung disease (such as asthma, cystic fibrosis, or bronchopulmonary dysplasia) * Inability to provide written informed consent Adult arm: * Contraindication to pulmonary function testing and cardiopulmonary exercise testing * Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of \>1 joint-year * Currently undergoing treatment for lung cancer * Inability to provide written informed consent No limitations will be placed on the type of e-liquids used by participants; e.g., e-cigarette users of nicotine, tetrahydrocannabinol, and cannabidiol will be all enrolled.

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Conditions

The condition(s) this trial relates to.

Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Small airways diseases VAPING Vaping behavior Vaping related disorder Vaping teens

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    8 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • BC Cancer Agency

    RECRUITING

    Vancouver, British Columbia, V5Z 4E6, Canada

  • BC Children's Hospital Research Institute

    RECRUITING

    Vancouver, British Columbia, V6H 3N1, Canada

  • McMaster University (Research Institute of St. Joe's Hamilton)

    NOT_YET_RECRUITING

    Hamilton, Ontario, L8N 4A6, Canada

  • St. Paul's Hospital

    RECRUITING

    Vancouver, British Columbia, V6Z 1Y6, Canada

  • University of Alberta (Clinical Sciences Building)

    RECRUITING

    Edmonton, Alberta, T6G 2B7, Canada

  • University of Ottawa (The Ottawa Hospital General Campus)

    RECRUITING

    Ottawa, Ontario, K1H 8L6, Canada

  • University of Toronto (The Hospital for Sick Children)

    NOT_YET_RECRUITING

    Toronto, Ontario, M5G 1E8, Canada

  • Université de Sherbrooke

    NOT_YET_RECRUITING

    Sherbrooke, Quebec, J1N 3C6, Canada

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