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Light therapy and strategic sleep may lift menopausal depression

NCT ID NCT06678880

Knowledge-focused Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 06, 2026 · Updated 4 times

Summary

This study looks at whether adjusting sleep timing and using bright light therapy can improve mood and sleep in perimenopausal women with depression. Researchers will have 120 women either advance or delay their sleep for one night, then use a light box for 30 minutes daily for two weeks. The goal is to understand how the body's internal clock affects depression during menopause.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bright white light therapy and sleep timing adjustment
What this could lead to
If successful, this could point toward a simple, non-drug treatment for depression during menopause by resetting the body's internal clock.
What could go wrong
This is an early, small study (120 participants) focused on understanding mechanisms, not proving a treatment works. Results may not apply to all women, and the sleep restriction involved could temporarily worsen mood or alertness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 75 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged 45-75 years old * Experiencing significant down, sad or hopeless feelings that are affecting their daily life * These mood changes started or got worse during the menopause transition * Irregular or no menstrual cycle for at least 6 months * Non-smoking * Located in San Diego County Exclusion Criteria: * Untreated sleep apnea * Migraine headaches that are triggered or worsened by bright light * Currently suicidal or psychotic * History of bipolar disorder * A medical condition or job where fatigue or changes in sleep schedule could be unsafe * Planning to start, stop, or change medications in the next 4 months

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression Depression during the menopausal transition Menopausal depression

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of California San Diego Hillcrest Medical Center

    RECRUITING

    San Diego, California, 92103, United States

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