New injection shows promise for stubborn nail infections
NCT ID NCT07311759
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new injection combining a steroid and antifungal drug against a standard topical cream for chronic paronychia, a long-lasting nail fold infection. Twenty-one adults with at least two affected fingernails on their dominant hand will receive both treatments on different fingers to see which works better. The goal is to find a more effective way to control this condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Triamcinolone acetonide and fluconazole injection
- What this could lead to
- If successful, this could offer a more effective treatment option for chronic paronychia, potentially reducing the need for long-term topical creams.
- What could go wrong
- This is a small trial with only 21 participants, so results may not apply to everyone. The injected treatment may cause pain or side effects, and it's unclear if it will be better than standard creams.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
About 21 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Aug 2024
- Expected to finish
-
May 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients with chronic paronychia affecting ≥ 2 fingernails in the dominant hand. 2. Patients not receiving any relevant systemic treatment for at least 4 weeks before initiation of our study 3. Patients not receiving any relevant topical treatment for at least 2 weeks before initiation of our study Exclusion Criteria: 1. Patient with peripheral vascular disease or Raynaud's phenomenon 2. Pregnant and lactating females 3. Patients with autoimmune diseases e.g., connective tissue diseases, psoriasis, reactive arthritis, and pemphigus. 4. Patients with solid or hematological malignancies. 5. Patients on systemic drugs that are known to cause chronic paronychia e.g. retinoids. 6. Patients with any visible focus of infection at the injection site or in the vicinity, including patients with superimposed attack of acute paronychia. 7. Onychomycosis or any associated nail disease
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Chronic paronychia are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cairo University
Cairo, Egypt