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Ankle cartilage repair therapy trial halted early

NCT ID NCT02537067

Disease control Sponsor: Cellontech Co., Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a treatment called Chondron, made from a patient's own cartilage cells, for repairing ankle cartilage defects. The trial aimed to see if the treatment could improve cartilage quality and ankle function over 18 months. However, the study was terminated early and included only 28 people, so the findings are limited.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Chondron (autologous cultured chondrocytes)
What this could lead to
If successful, this could provide a way to repair ankle cartilage damage, potentially reducing pain and improving joint function.
What could go wrong
The trial was terminated early with only 28 participants, so results are limited. Cartilage repair may not last or may require additional surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

28 people

The number who actually took part.

Start date

Jan 2010

Finished

Nov 2015

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female subjects aged 15 to 65 years * Patients with MRI-confirmed partial cartilage defects of the ankle (≤15 cm² single lesion, ≤20 cm² multiple lesions) * Patients who have undergone correction for malalignment, ligament instability, or bone defects (if applicable) * Patients with normal surrounding cartilage * Patients with ICRS Grade III or IV cartilage defects * Subjects who provide written informed consent Exclusion Criteria: * Hypersensitivity to bovine protein or gentamicin * Inflammatory or autoimmune arthritis (e.g., rheumatoid arthritis, gout) * Pregnant, breastfeeding, or planning pregnancy * Tumors or serious comorbid conditions * History of radiotherapy or chemotherapy within 2 years * Uncontrolled diabetes or diabetes with complications * Active infection requiring antibiotics * Current corticosteroid therapy * Patients with mental illness or other conditions deemed unsuitable for this study by the clinical trial manager

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Conditions

The condition(s) this trial relates to.

articular cartilage disorder joint laxity, familial osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankle (ligaments); instability, familial Defect of articular cartilage Degenerative joint disease of ankle and/or foot

Contacts and locations

Locations

  • Eulji General Hospital

    Seoul, Seoul, South Korea

  • Myongji Hospital

    Goyang-si, Gyeonggi-do, South Korea

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