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Could a single dose of choline boost brain activity in menopause?

NCT ID NCT07264257

Knowledge-focused Sponsor: University of Vermont Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a single 1650 mg dose of choline, a nutrient found in foods like eggs and meat, affects brain activity in postmenopausal women. Thirty-eight healthy women aged 50–65 took either choline or a placebo and had their brains scanned with fMRI while doing a memory task. The goal was to see if choline changes brain signals related to working memory.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Choline (dietary supplement)
What this could lead to
If it works, this could point toward a dietary supplement that supports brain function in postmenopausal women.
What could go wrong
This is a small, early-stage study with only 38 participants and a single dose. Results may not apply to long-term use or to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

38 people

The number who actually took part.

Started

Jun 2022

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 65 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged 50-65 years * Postmenopausal: Women who are postmenopausal will have not had a period in the last 12 months, have FSH\>30 IU/L, and estradiol (E2) \<50 pg/ml. * Nonsmokers * Not taking hormone therapy, SSRIs, phytoestrogens, SERMS, or antiestrogen medications and will be at least one year without such treatment * Physically healthy * No cardiovascular disease other than mild hypertension. Subjects will also not have current untreated or unremitted Axis I or II psychiatric or cognitive disorders (see screening below). * IQ in the normal range \>80 * Normal neuropsychological test performance Exclusion Criteria: * MCI or dementia - Montreal Cognitive Assessment \<26, Mattis Dementia Rating Scale \<130, and Global Deterioration Scale \>2 * History of cancer treatment with cytotoxic and/or ongoing (current) maintenance targeted chemotherapy * Blood pressure \> 160/100 (untreated) * Untreated thyroid disease * Significant cardiovascular disease * Asthma or COPD * Active peptic ulcer * Hyperthyroidism * Epilepsy * Current untreated or unremitted Axis I psychiatric disorders * Use of medications on the Prohibited medications (see list)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Menopause

Contacts and locations

Locations

  • University of Vermont

    Burlington, Vermont, 05401, United States

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