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Ancient herbs take on Drug-Resistant lung bug

NCT ID NCT07295938

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding Chinese herbs to standard treatment can help people with a hard-to-treat lung infection called Mycobacterium abscessus. The herbs aim to clear the bacteria from sputum and prevent the infection from coming back. About 352 adults who have finished the first phase of treatment will take either herbal capsules or a placebo for several months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Chinese herbs (two different herbal formulas)
What this could lead to
If it works, this could offer a safe, natural add-on treatment to help clear the infection and reduce the chance of it coming back.
What could go wrong
This is a mid-stage trial with 352 people, so results are not yet proven. Herbal treatments can vary in quality and may interact with other drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 352 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient diagnosed with Mycobacterium abscessus pulmonary disease; * Patients have completed the initial phase of treatment as recommended by the guidelines; * Patients who have given written informed consent * One week prior to enrollment, organ function levels must meet the following criteria: a. Hemoglobin ≥60g/L; b. Neutrophil count ≥0.5×10\^9/L; c. Platelet count ≥60×10\^9/L; d. Serum total bilirubin ≤3 times the upper limit of normal; e. Aspartate aminotransferase ≤3 times the upper limit of normal; f. Alanine aminotransferase ≤3 times the upper limit of normal; g. Creatinine level below 2 times the upper limit of normal or creatinine clearance ≥60mL/min; h. Urea nitrogen ≤200mg/L; i. Urinary protein \<++, with ≥500mg total protein in 24-hour urine if protein is present; j. Blood glucose: within normal range and/or stable blood glucose control in diabetic patients; k. Cardiac function: no history of myocardial infarction within 6 months; no unstable angina; no severe arrhythmia. Exclusion Criteria: * Patients with a drug allergy to the investigational medication; * Patients infected with two or more non-tuberculous mycobacteria, or those with active pulmonary tuberculosis; * Patients with a prior history of pulmonary parenchymal organ transplantation; * Patients with severe conditions such as congenital or acquired immunodeficiency disorders, active malignant tumors (primary or metastatic), or any malignancies requiring chemotherapy or radiotherapy during screening or study; * Patients undergoing dialysis; * Patients with radiation pneumonitis requiring corticosteroid or immunoglobulin pulse therapy, or clinically proven active interstitial lung disease, uncontrolled massive pleural effusion, or pericardial effusion; * Unstable systemic comorbidities (hypertensive crisis, unstable angina, congestive heart failure, myocardial infarction within the past 6 months, severe psychiatric disorders requiring medication, severe hepatic or renal dysfunction, neuropsychiatric conditions such as Alzheimer's disease); * Patients with intestinal dysfunction or malabsorption syndrome; * Pregnant or breastfeeding women; * Patients receiving other investigational drugs within 4 weeks prior to first exposure to the study drug; * Concurrent enrollment in another clinical trial, except for observational (non-interventional) studies or follow-up visits in interventional trials; * Physical examinations or clinical tests that the investigator deems potentially interfering with results or increasing treatment-related complications.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    8 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Anhui Provincial Chest Hospital

    RECRUITING

    Hefei, China

  • Beijing Chest Hospital Affiliated to Capital Medical University

    NOT_YET_RECRUITING

    Beijing, China

  • China-Japan Friendship Hospital

    NOT_YET_RECRUITING

    Beijing, China

  • Fudan University Affiliated Huashan Hospital

    NOT_YET_RECRUITING

    Shanghai, China

  • Guangzhou Municipal Hospital of Chest Medicine

    RECRUITING

    Guangdong, China

  • Jiangxi Chest Hospital

    NOT_YET_RECRUITING

    Nanchang, China

  • Longhua Hospital Affiliated Shanghai University of TCM

    RECRUITING

    Shanghai, China

  • Shanghai Pulmonary Hospital

    RECRUITING

    Shanghai, China

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