Early trial aims to train immune system to fight childhood cancers
NCT ID NCT04500548
Summary
This early-phase study aimed to test the safety and find the right dose of a two-drug immunotherapy (nivolumab and ipilimumab) for children, teens, and young adults whose cancers had returned or stopped responding to standard treatments. The drugs work by helping the patient's own immune system recognize and attack cancer cells. The trial specifically focused on cancers with a high number of genetic changes, as these may be more likely to respond to this type of treatment.
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Contacts and locations
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Locations
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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030, United States
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British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3V4, Canada
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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Lucile Packard Children's Hospital Stanford University
Palo Alto, California, 94304, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, 53792, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
Conditions
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