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Surgeons test innovative combo procedure for rare brain disorder

NCT ID NCT05754554

Disease control Sponsor: Southern Medical University, China Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new surgical procedure for people with Chiari malformation and type II skull base depression, a condition where brain tissue extends into the spinal canal. The surgery combined decompression, joint release, and fusion to relieve pressure and stabilize the spine. Researchers followed 64 patients to see if this approach improved symptoms and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgical procedure (atlanto-occipital decompression, lateral joint release, and occipital-neck fusion)
What this could lead to
If successful, this surgical approach could offer a more effective treatment for Chiari malformation with skull base depression, potentially improving symptoms and quality of life.
What could go wrong
This is a small, completed study with 64 participants, so results may not apply to everyone. Surgery carries risks like infection, nerve injury, or need for further procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Mar 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of Chiari malformation * Combined with type II skull base depression * Clinical symptoms related to the disease * Complete clinical imaging data * Must be the first surgery Exclusion Criteria: * Secondary cerebellar tonsillar hernia * Severe atlantoaxial dislocation * Osteochondroplastica * Rheumatoid arthritis * Down syndrome * Refurbished case reoperation

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Conditions

The condition(s) this trial relates to.

Chiari malformation Chiari malformation type II primary basilar invagination

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atlantoaxial dislocation Basilar invagination Chiari malformation

Contacts and locations

Locations

  • Nan fang hospital, Southern medical university

    Guangzhou, Guangdong, 510515, China

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