Stem cell boost may extend remission in brain cancer trial

NCT ID NCT01511562

Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether adding a stem cell transplant to standard chemotherapy helps people with newly diagnosed primary CNS B-cell lymphoma live longer without their cancer returning. About 113 patients will receive either high-dose chemo plus a stem cell transplant or chemo alone. The study aims to see which approach leads to better two-year progression-free survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: chemotherapy (carmustine, cytarabine, etoposide, thiotepa) and stem cell transplant
What this could lead to: If this trial succeeds, it could show that adding a stem cell transplant to chemotherapy improves how long patients stay cancer-free.
What could go wrong: This is a mid-stage trial with only 113 participants, so results may not apply to everyone. Stem cell transplant has serious risks, including infection and organ damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

113 people

The number who actually took part.

Start date

Sep 2012

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1. Documentation of Disease: Diagnosis of primary CNS diffuse large B-cell lymphoma confirmed by one of the following: brain biopsy or resection, cerebrospinal fluid and vitreous fluid. 2. Other Lymphomas: Patients must have no evidence or history of non-Hodgkin lymphoma (NHL) outside of CNS. 3. Previous Treatment: Patients must have no prior chemotherapy or radiation therapy for lymphoma. 4. Age- Patients must be between the ages of 18 and 75 years. 5. Karnofsky Performance Scale - Patients must measure Karnofsky Performance Scale ≥ 30 (≥ 50 for patients ages 60-70). 6. Pregnancy and Nursing Status - Patients must be non-pregnant and non-nursing; women of childbearing potential must have a negative serum or urine pregnancy test 10-14 days prior to registration; in addition, women and men of childbearing potential must commit to use an effective form of contraception throughout their participation in this study; appropriate methods of birth control include abstinence, oral contraceptives, implantable hormonal contraceptives, or double barrier method (diaphragm plus condom) 7. HIV - Patients must have negative HIV serology. 8. Hepatitis - Patients must have negative HCV serology (unless HBsAb positive patient has recently received HBV vaccine, in this case HBcAb should be negative). All patients must be screened for hepatitis B infection before starting treatment. Those patients who test positive for hepatitis B should be closely monitored for evidence of active HBV infection and hepatitis during and for several months after rituximab treatment. PCNSL patients with a history of hepatitis B infection should be treated with entecavir or lamivudine (physician discretion for choice of drug) as antiviral prophylaxis to prevent hepatitis B reactivation. 9. Organ Transplant or Immunosuppressant Therapy - Patient must have no history of organ transplantation or ongoing immunosuppressant therapy. 10. Required Initial Laboratory Values: ANC ≥ 1500/mcL, AST and ALT \< 2 x upper limit of normal (ULN), total bilirubin ≤ 3 mg/dL, creatinine clearance ≥ 50 mL/min, platelet count ≥ 100,000/mcL

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma diffuse large B-cell lymphoma of the central nervous system lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lymphoma

Contacts and locations

Locations

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States
Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States
Armes Family Cancer Center

Findlay, Ohio, 45840, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Bay Area Hospital

Coos Bay, Oregon, 97420, United States
Blanchard Valley Hospital

Findlay, Ohio, 45840, United States
Borgess Medical Center

Kalamazoo, Michigan, 49001, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
Cancer Care Center at Island Hospital

Anacortes, Washington, 98221, United States
Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, 05602, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Compass Oncology Vancouver

Vancouver, Washington, 98684, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dayton NCI Community Oncology Research Program

Dayton, Ohio, 45420, United States
Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States
Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States
Dayton Physicians LLC-Samaritan North

Dayton, Ohio, 45415, United States
Dayton Physicians LLC-Signal Point

Middletown, Ohio, 45042, United States
Dayton Physicians LLC-Upper Valley

Troy, Ohio, 45373, United States
Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331, United States
Dayton Physicians LLC-Wilson

Sidney, Ohio, 45365, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Emory University/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406, United States
Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States
Group Health Cooperative-Seattle

Seattle, Washington, 98112, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Katmai Oncology Group

Anchorage, Alaska, 99508, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Lakeland Community Hospital

Niles, Michigan, 49120, United States
Lakeland Hospital

Saint Joseph, Michigan, 49085, United States
Lewistown Hospital

Lewistown, Pennsylvania, 17044, United States
Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, 54601, United States
Mercy Health Mercy Campus

Muskegon, Michigan, 49444, United States
Mercy Health Saint Mary's

Grand Rapids, Michigan, 49503, United States
Metro Health Hospital

Wyoming, Michigan, 49519, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Minor and James Medical PLLC

Seattle, Washington, 98104, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, 98902, United States
Oncology Hematology Care Inc - Anderson

Cincinnati, Ohio, 45230, United States
Oncology Hematology Care Inc-Blue Ash

Cincinnati, Ohio, 45242, United States
Oncology Hematology Care Inc-Crestview

Crestview Hills, Kentucky, 41017, United States
Oncology Hematology Care Inc-Eden Park

Cincinnati, Ohio, 45202, United States
Oncology Hematology Care Inc-Healthplex

Fairfield, Ohio, 45014, United States
Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States
Oncology Hematology Care Inc-Mercy West

Cincinnati, Ohio, 45211, United States
Orion Cancer Care

Findlay, Ohio, 45840, United States
Pacific Gynecology Specialists

Seattle, Washington, 98104, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Providence Milwaukie Hospital

Milwaukie, Oregon, 97222, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Oncology and Hematology Care Southeast

Clackamas, Oregon, 97015, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Regional Cancer Partnership

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States
Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States
Reid Health

Richmond, Indiana, 47374, United States
Rockwood Cancer Treatment Center-DHEC-Downtown

Spokane, Washington, 99204, United States
Rockwood Clinic Cancer Treatment Center-Valley

Spokane Valley, Washington, 99216, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Luke's Mountain States Tumor Institute

Boise, Idaho, 83712, United States
Saint Luke's Mountain States Tumor Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Mountain States Tumor Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Mountain States Tumor Institute - Nampa

Nampa, Idaho, 83686, United States
Saint Luke's Mountain States Tumor Institute-Twin Falls

Twin Falls, Idaho, 83301, United States
Samaritan North Health Center

Dayton, Ohio, 45415, United States
Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Spectrum Health Reed City Hospital

Reed City, Michigan, 49677, United States
Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, 49503, United States
Springfield Regional Cancer Center

Springfield, Ohio, 45504, United States
Springfield Regional Medical Center

Springfield, Ohio, 45505, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Surgical Associates Inc

Tulsa, Oklahoma, 74136, United States
Swedish Cancer Institute-Eastside Oncology Hematology

Bellevue, Washington, 98005, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-Edmonds

Edmonds, Washington, 98026, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122-4307, United States
Tulane University Health Sciences Center

New Orleans, Louisiana, 70112, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCSF Medical Center-Mount Zion

San Francisco, California, 94115, United States
UCSF Medical Center-Parnassus

San Francisco, California, 94143, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States
University of Rochester

Rochester, New York, 14642, United States
University of Vermont College of Medicine

Burlington, Vermont, 05405, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
University of Wisconsin Hospital and Clinics

Madison, Wisconsin, 53792, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298, United States
Warren Clinic Oncology-Tulsa

Tulsa, Oklahoma, 74146, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne Hospital

Greenville, Ohio, 45331, United States
Weill Medical College of Cornell University

New York, New York, 10065, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
Yale University

New Haven, Connecticut, 06520, United States

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