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New hope for myeloma patients: drug combo aims to keep cancer at bay

NCT ID NCT07555938

Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 4 times

Summary

This study tests whether adding the experimental drug cevostamab to standard medications (pomalidomide and dexamethasone) works better than current treatments for multiple myeloma. About 380 adults whose cancer came back after 1 to 3 prior therapies will take part. The goal is to see if the combination can make the cancer disappear completely or delay its return.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 380 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jan 2033

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 at screening and immediately prior to start of administration of study treatment. * Individuals with ECOG Performance Status of 2 solely due to local symptoms of myeloma (e.g., pain) are eligible * MM diagnosis according to the International Myeloma Working Group (IMWG) diagnostic criteria * Received one to three lines of prior therapy that included at least two consecutive cycles of either of the following: A regimen containing an anti-CD38 therapy, a regimen containing lenalidomide * Participants must have measurable disease during screening Exclusion Criteria: * Known history of amyloidosis (e.g., positive Congo Red stain or equivalent in tissue biopsy or documented within serum amyloid P component scan) * Plasma cell leukemia or circulating plasma cell count exceeding 500 cells/liter (L) or 5% of the peripheral blood white cells * GI disease that might significantly alter absorption of oral drugs * Participants must not have any ongoing CNS disease or non-secretory myeloma

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple myeloma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    75 sites in 16 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aarhus Universitetshospital

    RECRUITING

    Aarhus, 8000, Denmark

  • Alexandras General Hospital of Athens

    RECRUITING

    Athens, 11528, Greece

  • Anticancer Hospital of Thessaloniki " Theagenio"

    RECRUITING

    Thessaloniki, 540 07, Greece

  • Asan Medical Center

    RECRUITING

    Seoul, 05505, South Korea

  • Asst Papa Giovanni Xxiii

    RECRUITING

    Bergamo, Lombardy, 24127, Italy

  • Auxilio Mutuo Cancer Center

    RECRUITING

    San Juan, 917, Puerto Rico

  • Chaim Sheba Medical Center

    RECRUITING

    Ramat Gan, 5266200, Israel

  • Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin

    RECRUITING

    Berlin, 12200, Germany

  • Chonnam National University Hwasun Hospital

    RECRUITING

    Jeollanam-do, 58128, South Korea

  • City of Hope - Lennar Foundation Cancer Center

    RECRUITING

    Irvine, California, 92618, United States

  • City of Hope National Medical Center

    RECRUITING

    Duarte, California, 91010-3012, United States

  • Clinica Universitaria de Navarra

    RECRUITING

    Pamplona, Navarre, 31008, Spain

  • Dokkyo Medical University Saitama Medical Center

    RECRUITING

    Saitama, 343-8555, Japan

  • Emory University Hospital Midtown

    RECRUITING

    Atlanta, Georgia, 30308, United States

  • Evangelismos General Hospital of Athens

    RECRUITING

    Athens, 106 76, Greece

  • Fakultni nemocnice Hradec Kralove

    RECRUITING

    Hradec Králové, 500 05, Czechia

  • Fakultni nemocnice Ostrava

    RECRUITING

    Ostrava, 708 52, Czechia

  • Forsythe Memorial Hospital Inc., dba Novant Health Oncology Specialists

    RECRUITING

    Winston-Salem, North Carolina, 27103, United States

  • Gunma University Hospital

    RECRUITING

    Gunma, 371-8511, Japan

  • HELIOS Klinikum Bad Saarow

    RECRUITING

    Bad Saarow, 15526, Germany

  • Hadassah Ein Karem Hospital

    RECRUITING

    Jerusalem, 9112001, Israel

  • Hamilton Health Sciences - Juravinski Cancer Centre

    RECRUITING

    Hamilton, Ontario, L8V 1C3, Canada

  • Hospital Clinic i Provincial de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Clinico Universitario de Salamanca

    RECRUITING

    Salamanca, 37007, Spain

  • Hospital Costa del Sol

    RECRUITING

    Marbella, Malaga, 29603, Spain

  • Hospital General Universitario Gregorio Marañon

    RECRUITING

    Madrid, 28009, Spain

  • Hospital Israelita Albert Einstein

    RECRUITING

    São Paulo, São Paulo, 05652-000, Brazil

  • Hyogo Medical University Hospital

    RECRUITING

    Hyōgo, 663-8501, Japan

  • IRCCS Istituto Romagnolo per lo studio dei tumori "Dino Amadori"

    RECRUITING

    Meldola, Emilia-Romagna, 47014, Italy

  • Ichilov Sourasky Medical Center

    RECRUITING

    Tel Aviv, 6423906, Israel

  • Istituto Clinico Humanitas

    RECRUITING

    Rozzano, Lombardy, 20089, Italy

  • Iwate Medical University Hospital

    RECRUITING

    Numakunai, 028-3695, Japan

  • Japanese Red Cross Medical Center

    RECRUITING

    Shibuya-ku, 150-8935, Japan

  • Marien-Hospital Klinik f.Hämatologie Onkologie u.Palliativmedizin

    RECRUITING

    Düsseldorf, 40479, Germany

  • Matsuyama Red Cross Hospital

    RECRUITING

    Ehime, 790-8524, Japan

  • MedStar Washington Hospital Center MedStar Georgetown Cancer Institute

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Nagoya City University Hospital

    RECRUITING

    Aichi, 467-8602, Japan

  • Nanfang Hospital, Southern Medical University

    RECRUITING

    Guangzhou, 510515, China

  • Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School

    RECRUITING

    Nanjing, Jiangsu, 210008, China

  • Narodowy Instytut Onkologii im. Marii Sk?odowskiej-Curie - Pa?stwowy Instytut Badawczy

    RECRUITING

    Warsaw, 02-721, Poland

  • National Hospital Organization Okayama Medical Center

    RECRUITING

    Okayama, 701-1192, Japan

  • Novant Health Cancer Institute

    RECRUITING

    Charlotte, North Carolina, 28204, United States

  • Osaka University Hospital

    RECRUITING

    Osaka, 565-0871, Japan

  • Qilu Hospital of Shandong University

    RECRUITING

    Jinan, 250012, China

  • Rambam Health Care Campus

    RECRUITING

    Haifa, 31096, Israel

  • Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

    RECRUITING

    Shanghai, 200127, China

  • SP ZOZ Szpital Uniwersytecki w Krakowie-Jakubowskiego 2;Oddzial Kliniczny Hematologii

    RECRUITING

    Krakow, Lesser Poland Voivodeship, 30-688, Poland

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, 03080, South Korea

  • Seoul St Mary's Hospital

    RECRUITING

    Seoul, 06591, South Korea

  • Severance Hospital, Yonsei University Health System

    RECRUITING

    Seoul, 03722, South Korea

  • St Vincent's Hospital Melbourne

    RECRUITING

    Fitzroy, Victoria, 3065, Australia

  • Sun yat-sen University Cancer Center

    RECRUITING

    Guangzhou, Guangdong, 510555, China

  • Sygehus Lillebælt, Vejle;Hæmatologisk Forskningsenhed, HKFE

    RECRUITING

    Vejle, 7100, Denmark

  • The Affiliated Hospital Of Qingdao University

    RECRUITING

    Qingdao, Shandong, 266003, China

  • The Cancer Institute Hospital of JFCR

    RECRUITING

    Tokyo, 135-8550, Japan

  • The First Affiliate Hospital of Guangxi Medical University

    RECRUITING

    Nanning, 530021, China

  • The First Affiliated Hospital of Soochow University

    RECRUITING

    Suzhou, 215006, China

  • The First Affiliated Hospital of Wenzhou Medical University

    RECRUITING

    Wenzhou, 325035, China

  • The First Affiliated Hospital, Zhejiang University School of Medicine - Qingchun Campus - PPDS

    RECRUITING

    Hangzhou, Zhejiang, 310003, China

  • The First Affilliated Hospital of Kunming Medical University

    RECRUITING

    Kunming, Yunnan, 650032, China

  • Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

    RECRUITING

    Wuhan, 430030, China

  • Toyohashi Municipal Hospital

    RECRUITING

    Toyohashi, Aichi-ken, 441-8570, Japan

  • TriHealth Cancer and Blood Institute

    RECRUITING

    Cincinnati, Ohio, 45220, United States

  • UKSH, Campus Kiel

    RECRUITING

    Kiel, 24105, Germany

  • University Hospital Kyoto Prefectural University of Medicine

    RECRUITING

    Kyoto, 602-8566, Japan

  • Universitätsklinikum Frankfurt

    RECRUITING

    Frankfurt, 60590, Germany

  • Universitätsmedizin Greifswald

    RECRUITING

    Greifswald, 17475, Germany

  • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu

    RECRUITING

    Wroc?aw, 50-367, Poland

  • Uniwersyteckie Centrum Kliniczne

    RECRUITING

    Gda?sk, 80-214, Poland

  • Vivantes Klinikum Am Urban Klinik für Innere Medizin Hämatologie und Onkologie

    RECRUITING

    Berlin, 10967, Germany

  • West Virginia University

    RECRUITING

    Morgantown, West Virginia, 26506, United States

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06510, United States

  • Yamagata University Hospital

    RECRUITING

    Yamagata, 990-9585, Japan

  • Zhongshan Hospital Fudan University

    RECRUITING

    Shanghai, 200032, China

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