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Why some back pain lingers: researchers probe the nervous System's role

NCT ID NCT07826546

Knowledge-focused Sponsor: Mardin Artuklu University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers are studying whether heightened sensitivity in the nervous system predicts how adults with chronic nonspecific low back pain fare over six weeks. About 180 participants aged 18 to 65 complete questionnaires at the start about central sensitization, disability, pain, anxiety, and depression. After six weeks, the team measures disability, pain, and each person's sense of change, then checks whether initial sensitization levels track with meaningful improvement. Participants receive routine clinical care and are not assigned to any study treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If a link holds up, doctors could one day use a simple questionnaire to spot which low back pain patients are less likely to improve with routine care and steer them toward different treatment sooner.
What could go wrong
This is an observational study, so it can show an association but cannot prove that central sensitization causes poorer outcomes. Results from 180 adults may not apply to everyone with low back pain, and participants keep receiving routine care rather than a study treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 18-65 years with chronic nonspecific low back pain lasting for at least 3 months will be recruited from the Physical Medicine and Rehabilitation outpatient clinic of Mardin Training and Research Hospital. Participants will receive routine clinical care and will be evaluated at baseline and after 6 weeks. No healthy control group will be included.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 65 years * Diagnosis of chronic nonspecific low back pain lasting for at least 3 months * Willingness to participate in the study * Ability to provide written informed consent Exclusion Criteria: * Progressive neurological deficit * Inflammatory rheumatic disease * Active malignancy * History of serious spinal trauma or spinal surgery * Cognitive impairment that may prevent completion of the assessments or follow-up * Initiation, dose modification, or change of antidepressant or gabapentinoid treatment within the previous 3 months * Pregnancy, postpartum period, or breastfeeding * Inability to provide informed consent

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic nonspecific low back pain

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mardin Training and Research Hospital

    RECRUITING

    Mardin, 47100, Turkey (Türkiye)

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