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Experimental lymphoma therapy tested in tiny early trial

NCT ID NCT05994157

Disease control Sponsor: Y-mAbs Therapeutics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 1 trial tested a two-step radioimmunotherapy (CD38-SADA and 177Lu-DOTA) in patients with relapsed or refractory non-Hodgkin lymphoma. The goal was to find safe doses and dosing schedules. Only 1 participant was enrolled, and the study was terminated early, so no conclusions about effectiveness can be drawn.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CD38-SADA and 177Lu-DOTA (two-step radioimmunotherapy)
What this could lead to
If it works, this could point toward a new treatment option for patients with hard-to-treat non-Hodgkin lymphoma.
What could go wrong
This was a very early, small phase 1 trial with only 1 participant, and it was terminated early. It is unclear if the approach is safe or effective, and it may not work in larger groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

1 person

The number who actually took part.

Started

Apr 2025

Finished

Oct 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Target population must have relapsed, progressive or refractory non-hodgkin lymphoma and be ineligible for or have exhausted standard therapeutic options that may prolong survival * The subject must have fluoro-deoxyglucose (FDG)-avid lymphoma with measurable disease * CD38 positive tumor at most recent biopsy (new or archival) documented at central laboratory * Subject must have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or 2 * Each subject must sign an ICF indicating that he or she understands the purpose of, and procedures required for the trial and is willing to participate in the trial. Exclusion Criteria: * Primary central nervous system lymphoma or known central nervous system involvement with lymphoma * Systemic chemotherapy, radiotherapy, immunotherapy, or major surgery administered within 3 weeks (for nitrosoureas within 6 weeks) prior to the first dose of CD38-SADA * Radioimmunotherapy within 100 days prior to the first dose of CD38-SADA * Autologous stem cell transplantation within 42 days prior to the first dose of CD38-SADA * Treatment with approved CAR-T within 100 days prior to the first dose of CD38-SADA * \>40% lymphoma bone marrow involvement

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Conditions

The condition(s) this trial relates to.

non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-Hodgkin lymphoma

Contacts and locations

Locations

  • City of Hope

    Duarte, California, 91010, United States

  • Corewell Health-BAMF Health

    Grand Rapids, Michigan, 49503, United States

  • East Carolina University Leo W. Jenkins Cancer Center

    Greenville, North Carolina, 27834, United States

  • HonorHealth

    Scottsdale, Arizona, 85258, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Stony Brook Cancer Center

    Stony Brook, New York, 11794, United States

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