Could a simple collagen shot ease your knee pain?
NCT ID NCT02539095
First seen Jun 24, 2026 · Last updated Jun 24, 2026
Summary
This study tested whether injecting a collagen product called CartiZol into the knee joint can reduce pain in people with knee problems like osteoarthritis or cartilage damage. Two hundred adults received either the collagen injection or a placebo (salt water). The main goal was to see if pain scores improved after 24 weeks. The trial is complete, and results will show if this approach is better than a placebo for easing knee pain.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Chung-Ang University Hospital
Seoul, South Korea
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Kunkuk University Medical Center
Seoul, South Korea
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Samsung Medical Center
Seoul, South Korea
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The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, South Korea
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The Catholic University of Korea, Yeouido St. Mary's Hospital
Seoul, South Korea
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CartiZol (type I atelocollagen injection)
What this could lead to
If it works, this could offer a new, non-surgical option for reducing knee pain in people with cartilage damage or early osteoarthritis.
What could go wrong
This is a single, completed Phase 4 trial with 200 participants. The results may not apply to everyone, and the effect might be small or short-lived. Placebo-controlled design helps but doesn't guarantee real-world benefit.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.