First-in-Human trial tests engineered immune cells against tough prostate cancer
NCT ID NCT05022849
Summary
This is an early-stage study to find a safe dose of a new experimental treatment called JNJ-75229414 for men with metastatic prostate cancer that no longer responds to standard hormone therapy. The treatment involves collecting a patient's own immune cells (T cells), genetically modifying them in a lab to target a protein called KLK2 found on prostate cancer cells, and then infusing them back into the patient. The main goals are to check for side effects and see how the body handles the treatment in about 15 participants.
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Contacts and locations
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Locations
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City of Hope Cancer Center
Duarte, California, 91010, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Levine Cancer Institute
Charlotte, North Carolina, 28204, United States
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Norton Cancer Institute
Louisville, Kentucky, 40207, United States
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University Of Minnesota
Minneapolis, Minnesota, 55455, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Utah Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
Conditions
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