One-Time immune cell infusion tested as powerful new weapon against Tough-to-Treat blood cancer

NCT ID NCT05396885

Ongoing Disease control Sponsor: Kite, A Gilead Company Source: ClinicalTrials.gov ↗

Summary

This study is testing a single infusion of a patient's own genetically modified immune cells (called CART-ddBCMA) to fight multiple myeloma that has returned or stopped responding to other treatments. It aims to see how well this one-time therapy controls the cancer and how safe it is for patients. The treatment involves collecting a patient's T-cells, modifying them in a lab to target the cancer, and then infusing them back after a short course of chemotherapy.

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Contacts and locations

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Locations

Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Froedtert Hospital & the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
HonorHealth Cancer Transplant Institute

Scottsdale, Arizona, 85258, United States
Huntsman Cancer Institute, University of Utah

Salt Lake City, Utah, 84112, United States
John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Northside Hospital

Atlanta, Georgia, 30342, United States
Oregon Health & Science University (OHSU)

Portland, Oregon, 97239, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of Chicago Medical Center

Chicago, Illinois, 60637, United States
University of Maryland Greenebaum Comprehensive Cancer Center

Baltimore, Maryland, 21201, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Wisconsin Clinical Science Center

Madison, Wisconsin, 53792, United States

Conditions

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MULTIPLE MYELOMA